Multi-resolution methods for modelling intracellular processes

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234)

Abstract: I will discuss the development, analysis and applications of multi-resolution methods for spatio-temporal modelling of intracellular processes, which use (detailed) Brownian dynamics or molecular dynamics simulations in localized regions of particular interest (in which accuracy and microscopic details are important) and a (less-detailed) coarser model in other regions in which accuracy may be traded for simulation efficiency. I will discuss the error analysis and convergence properties of the developed multi-resolution methods, their software implementation and applications of these multiscale methodologies to modelling of intracellular calcium dynamics, actin dynamics and DNA dynamics. I will also discuss the development of multiscale methods which couple molecular dynamics and coarser stochastic models in the same dynamic simulation.