Theoretical studies on biological oscillations by using waveform data and mathematical models – Shingo Gibo

Title: Theoretical studies on biological oscillations by using waveform data and mathematical models

Abstract: Temporal waveforms of biological oscillations are of various shapes. In our research, we have explored the functional implications of these waveform shapes. In particular, we theoretically showed that the period of circadian clocks is proportional to the waveform distortion from sinusoidal wave. It suggests that the circadian period can be stable against temperature changes only if the waveform becomes more distorted at higher temperatures. In this talk, I will explain my past research and discuss my future plans.

Reference:
[1] Shingo Gibo, Gen Kurosawa, Non-sinusoidal Waveform in Temperature Compensated Circadian Oscillations, Biophysical Journal 116 (4) 741-751 (2019). doi: 10.1016/j.bpj.2018.12.022
[2] Shingo Gibo, Gen Kurosawa, Theoretical study on the regulation of circadian rhythms by RNA methylation, Journal of Theoretical Biology 490, 110140 (2020). doi; 10.1016/j.jtbi.2019.110140
[3] Shingo Gibo, Teiji Kunihiro, Tetsuo Hatsuda, Gen Kurosawa, Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the renormalization group method, arXiv (2024). arXiv:2409.02526