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명경재

DirectorMyung Kyungjae

  • Myung Kyungjae DirectorMyung Kyungjae
  • LEE Kyooyoung Research FellowLEE Kyooyoung
  • HAN Jooseok Research FellowHAN Jooseok
  • KANG Sukhyun Research FellowKANG Sukhyun
  • PARK Junhong Research FellowPARK Junhong
  • KIM Taemoon Research FellowKIM Taemoon
  • PARK Youngun Research FellowPARK Youngun
  • LEE Yoonsung Research FellowLEE Yoonsung

Identifying DNA repair mechanisms to cure cancer and explain aging

Contact Info

Tel. +82-52-217-5514

Address

IBS Center for Genomic Integrity
UNIST-gil 50, Ulsan, 689-798, Republic of Korea

Director
Director Myung Kyungjae

Director Myung Kyungjae

Professor Myung is the director of the Center for Genomic Integrity, established in December 2014. In 1991 he received his B.S. in Zoology and then in 1993 earned his M.S. in Molecular Biology, both from Seoul National University. He completed his Ph.D. in Molecular Biology, Cell Biology and Biochemistry at Brown University in 1999.
Later he became the Senior Investigator and Section Head at the National Human Genome Research Institute, He returned to Korea and took up his position at IBS.

Introduction
graphic image for Research Center

Uncovering DNA repair pathways to reveal the origin of cancers, aging and evolution

  • - Enhancing the efficiency and accuracy of genome engineering techniques
  • - Investigating gene functions through gene knockout screening
  • - Applying genome engineering techniques to human stem cells and establishing a cell bank
  • - Using genome editing to develop new therapies for intractable diseases
Main research activities

DNA is a building block for entire the genome and encodes genetic codes, which determine almost every aspect of life. In some cases DNA could be damaged by endogenous asserts such as replication errors and oxidation stresses or exogenous challenges such as radiation or toxic chemicals. If such damage were not properly repaired, cells could die or accumulate mutations that would cause aging and genetic diseases including cancers. Cells equip multiple DNA repair pathways that can sense, transduce signals, and ultimately repair damaged DNA. These pathways sometimes participate other DNA metabolisms including DNA replication, transcription, and recombination. The Center for Genomic Integrity will investigate these multiple DNA repair pathways at the molecular level using small molecules with molecular, cell biological and biochemical techniques and animal models. We anticipate our research will uncover detail molecular mechanisms of DNA replication, repair, and recombination and come up with potential answers the origin of cancers, aging, and evolution.

Organization

Organization

Main research results
  • Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination
    (Journal of Cell Biology, 2006)
  • Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
    (PNAS, 2008)
  • High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death
    (PNAS, 2012)
  • Human ATAD5 regulates the lifespan of DNA replication factories
    (Journal of Cell Biology, 2013)
Personnel
Personnel status
Total50
Gender26(Male), 24(Female)
Korean/ International46(Korean), 4(International)
Degree
Position

As of Dec. 2015

Research

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Content Manager
Center for Genomic Integrity : Chang Ga Young   052-217-5539
Last Update 2017-01-12 10:12