주요메뉴 바로가기 본문 바로가기

주메뉴

IBS Conferences

김은준

DirectorKIM Eunjoon

  • KIM Eunjoon DirectorKIM Eunjoon
  • JUNG Min Whan Associate DirectorJUNG Min Whan

Investigating synaptic proteins to conquer mental disorders

Contact Info

Tel. 042-350-8125

Address

IBS Center for Synaptic Brain Dysfunctions
Room 2209, Dept. of Biological Sciences, Natural Science B/D(E6-3), KAIST,
291, Daehak-ro, Yuseong-gu, Daejeon

Director
Director KIM Eunjoon

Director KIM Eunjoon

Professor Kim is the director of the Center for Synaptic Brain Dysfunctions, established in July 2012. He earned his B.S. from Busan National University before getting his Ph.D. in Pharmacology and Toxicology from Michigan State University in 1994 and later worked in the Department of Neurobiology and Howard Hughes Medical Institute at Harvard Medical School. In 2003 he became the Director of the National Creative Research Initiative Center for Synaptogenesis before taking up his position in IBS.

Introduction
graphic image for Research Center

Exploring key neural mechanisms underlying synaptopathies

  • - Understanding key mechanisms of synaptic brain dysfunctions
  • - Understanding neural mechanisms of decision making and episodic memory
Main research activities

A large number of proteins including receptors, signaling proteins, and scaffolding proteins participate in the molecular organization of neuronal synapses. We have been studying the molecular mechanisms underlying the formation, differentiation, maintenance, and the dynamic plasticity of neuronal synapses. Many synaptic proteins have recently been associated with a variety of neuropsychiatric developmental disorders including autism, attention deficit/hyperactivity disorder (ADHD), schizophrenia, intellectual disability, and emotional disorders.

This concept of the association between defective synaptic proteins and brain dysfunctions has recently been termed "synaptopathy". Our center will be exploring key neural mechanisms underlying synaptopathies. To this end, we will perform researches using systems approaches (including cultured neurons, brain slices, and transgenic mice), in combination with molecular, cell-biological, anatomical, electrophysiological, and behavioral approaches.

Organization

Organization

Main research results
  • Distinct Roles of Parvalbumin- and Somatostatin-Expressing interneurons in Working Memory
    (NEURON. 2016)
  • Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity
    (Nature Neuroscience. 2016)
  • SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion.
    (Nature Communications. 2015)
  • Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression.
    (Nature Neuroscinece. 2015)
  • Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation.
    (Nature Communications, 2015)
Personnel
Personnel status
Total71
Gender33(Male), 38(Female)
Korean/ International68(Korean), 3(International)
Degree
Position

As of March. 2017

Research

Are you satisfied with the information on this page?

Content Manager
Center for Synaptic Brain Dysfunctions : Song, Eun Ju   042-350-8125
Last Update 2017-04-10 16:44