Conquering immune disorders
IBS Academy of Immunology and Microbiology
Room 286, POSTECH Biotech Center, POSTECH,
77, Cheongam-ro, Nam-gu, Pohang-si, Gyeongsangbuk-do
Director Charles SURH
Professor Surh is the director of the Academy of Immunology and Microbiology(AIM), stablished in August 2012. In 1983 he received his B.S. in Chemistry from UC San Diego, and in 1989 earned his Ph.D. in Immunology from UC Davis. He previously worked at the Department of Immunology at The Scripps Research Institute, La Jolla, California from 1989.
In 2009 he became a Professor at the Division of Integrative Biosciences & Biotechnology at POSTECH before becoming an IBS director.
Understanding immune homeostatic mechanisms between commensal microbes and host immune system
The immune system is essential to protect the host from invasion by pathogenic microbes and outgrowth of cancerous host cells. It is both powerful and versatile, capable of mobilizing a customized potent response to the vast array of pathogens and tumors. Because of its strength, the activated immune response is tightly regulated and is, upon elimination of the invaders, rapidly extinguished to prevent collateral tissue damage. The immune system thereafter “remembers” the invaders, and is capable of mounting a stronger and quicker response to subsequent invasions by the same pathogen or cancer.
Effective immunity requires a complex network of interactions between multiple types of cells. The primary lymphoid tissues generate immune cells, whose activation is initiated in the secondary lymphoid tissues. Immune cells are also distributed throughout the non-lymphoid tissues and are particularly prominent in the mucosal tissues that are exposed to the environment. Here, these immune cells perform a highly specialized function by providing protection from environmental pathogens, while maintaining operational tolerance to benign antigens and to the massive numbers of commensal microbes that co-exist peacefully with the host.
While many key mechanisms that regulate the immune system have been deciphered, many more have yet to be discovered. The goal of Academy of Immunology and Microbiology (AIM) is to discover several of these unknown fundamental mechanisms. Particular focus will be placed on elucidating the mechanisms by which various populations of lymphocytes develop and function, how these cells are activated and regulated in order to protect the host without causing collateral tissue damage, and how these cells co-exist peacefully with the commensal microbes while conferring protective immunity against pathogenic microbes. These discoveries should reveal novel approaches to enhance immunity against pathogens and cancer and to prevent or ameliorate chronic immune inflammatory diseases, such as autoimmunity, allergies, atherosclerosis and metabolic diseases.
|Korean/ International||41(Korean), 7(International)|
As of Dec. 2015