Targeted crystallization of mixed-charge nanoparticles in lysosomes for inducing selective death of cancer cells

[특허 요약] The present invention relates to a mixed-charge nanoparticle for inducing selective death of cancer cells and a use thereof. The mixed-charge nanoparticle of the present invention is localized and crystallized specifically in cancer cell lysosomes through a pH-dependent aggregation behavior due to the balance between positively charged ligands and negatively charged ligands on the surface thereof and can induce lysosomal membrane permeabilization (LMP) and lysosomal cell death mediated thereby, like cationic amphiphilic drugs (CADs) Exhibiting a cancer cell-specific death effect, the nanoparticles of the present invention can surmount the limited medical use of conventional cationic nanoparticles due to the non-specific cytotoxicity thereof. Particularly, the nanoparticles of the present invention do not exhibit toxicity to the human body and normal cells, thus finding useful applications in medical and medicinal uses such as for prevention and treatment of solid cancer, blood cancer, and tumors.

특허 등록번호

20230211011A

특허 출원번호

202117800990

출원일

2021.02.22

등록일

2023.07.06

국가

미국

출원인

기초과학연구원, 울산과학기술원

발명자

Bartosz Grzybowski, Kristiana Kandere-Grybowska, Magdalena Borkowaska, Marta Siek, Diana Kolygina

중요 키워드

nanoparticles, cells, mixed, charge, group