[특허 요약] The present invention relates to a Magnetic Torquer (m-Torquer) conjugate-based drug. Specifically, according to the present invention, an m-Torquer conjugate, comprising: (a) a magnetic nanoparticle that generates rotational force upon application of a controlled rotating magnetic field, wherein the working distance from the rotating magnetic field generator is at least 1 cm, preferably at least 2 cm, 10 cm, more preferably at least 20 cm, 30 cm, and most preferably at least 60 cm or 70 cm; (b) a binding moiety that binds to a drug target protein present in the biological lipid membrane; and (c) a linker or a direct attachment between the magnetic nanoparticle and the binding moiety, wherein, when the m-Torquer conjugate binds to the drug target protein, the rotational force generated by the magnetic nanoparticle upon application of a controlled rotating magnetic field is transmitted to the drug target protein, inducing a conformational change in the drug target protein. Accordingly, the m-Torquer conjugate-based drug may be used as a therapeutic agent that modulates biological signaling, structural integrity, metabolism, function, and regulation in the body.

등록번호

4574132A

출원번호

23855169

출원인

연세대학교 산학협력단, 기초과학연구원

키워드

torquer, conjugate, drug, magnetic field, based drug