Composition for inducing apoptosis of cells having genomic sequence variation and method for inducing apoptosis of cells by using composition

[특허 요약] The present invention relates to at least one delivery vehicle comprising: either a plurality of cleavaging agents that specifically recognize a plurality of nucleic acid sequences including unique sequences, which do not exist in normal cells, among variant region sequences specific for cells having genomic sequence variation in the cells having genomic sequence variation, or polynucleotides encoding the cleavaging agents; and a nuclease or a polynucleotide encoding the nuclease. The present invention also relates to a composition containing the delivery vehicle, and a method of inducing apoptosis of cells having genomic sequence variation by using the delivery vehicle or the composition.

특허 등록번호

20230096378A

특허 출원번호

202117911018

출원일

2021.03.12

등록일

2023.03.30

국가

미국

출원인

기초과학연구원, 울산과학기술원

발명자

Kyungjae MYUNG, Taejoon Kwon, In-Joon BAEK, Jae Sun RA, Yong Hwan PARK, Woojae JUNG, Daniyar OTARBAYEV, Seungwoo CHO

중요 키워드

cells, cleavaging, agents, genomic sequence, sequence variation