STRUCTURAL AND FUNCTIONAL PROPERTIES OF YEAST-DERIVED POLYSACCHARIDE-INDUCING TREG CELLS

[특허 요약] The present invention relates to a yeast-derived polysaccharide inducing Treg cells and a use thereof and, more particularly, to a polysaccharide comprising mannan and β-glucan, an composition for immunomodulation comprising the polysaccharide as an active ingredient, a pharmaceutical composition or food comprising the polysaccharide as an active ingredient for prevention or treatment of immune disease or inflammatory disease, a method for preparation of regulatory T cells by using the polysaccharide, a cell therapeutic agent comprising the regulatory T cells prepared by the preparation method as an active ingredient, and a treatment method using same. Even at a low dose, the novel polysaccharide according to the present invention allows the production of tolerogenic antigen presenting cells through the β-glucan and mannan structure retained therein, whereby the novel polysaccharide can induce the differentiation or production of antigen-specific regulatory T cells (Treg cells) to modulate the target immune system with low adverse effects. Therefore, MGCP and the Treg cells induced by the polysaccharide are effective for preventing or treating immune disease or inflammatory disease.

특허 등록번호

3868390A

특허 출원번호

19874049

출원일

2019.07.29

등록일

2022.07.20

국가

유럽_특허청

출원인

기초과학연구원, 포항공과대학교 산학협력단

발명자

Sin-Hyeog Im, Verma RAVI, Changhon LEE

중요 키워드

yeast, structural, functional properties, treg cells, derived polysaccharide