Ultrafine iron oxide nanoparticle-based magnetic resonance imaging t1 contrast agent

[특허 요약] Provided is a T1 contrast agent for magnetic resonance imaging. The T1 contrast agent includes fine iron oxide nanoparticle cores and micelles encapsulating the core particles. The micelles include a nonionic surfactant consisting of a hydrophilic moiety containing at least two chains and a hydrophobic moiety containing at least one C10-C30 hydrocarbon chain. The T1 contrast agent of the present invention is a novel one based on fine iron oxide nanoparticles that can replace conventional gadolinium-based T1 contrast agents. The T1 contrast agent based on fine iron oxide nanoparticles according to the present invention is harmless to humans, is rapidly distributed in the blood, and has a uniform size, ensuring its uniform contrast effect. In addition, the T1 contrast agent of the present invention enables image observation for at least 1 hour to up to 2 hours and is excreted through the kidneys and liver. Therefore, the T1 contrast agent of the present invention avoids the problems encountered in conventional gadolinium-based contrast agents.

특허 등록번호

20220143225A

특허 출원번호

201917437353

출원일

2019.12.17

등록일

2022.05.12

국가

미국

출원인

서울대학교산학협력단, 기초과학연구원, 서울대학교병원

발명자

Yun Sang Lee, Taeg Hwan Hyeon, Jae Min Jeong, Jae Sung Lee, Ji Yong Park, Kyu Wan Kim, Jae Hwan Shin, Guen Bae KO, Whal LEE, Eun Ah Park

중요 키워드

iron oxide, nanoparticles, contrast agent, core particles, contrast