Device and method for measuring central location of single molecule using structured illumination and phase detection

[특허 요약] According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.

특허 등록번호

11550136B

특허 출원번호

201816757470

출원일

2018.10.16

등록일

2023.01.10

국가

미국

출원인

고려대학교 산학협력단, 기초과학연구원

발명자

Sang Hee Shim, Ji Woong KWON

중요 키워드

light, single molecule, structured illumination, generated, polarization