{"id":7805,"date":"2023-05-29T12:23:27","date_gmt":"2023-05-29T03:23:27","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&#038;p=7805"},"modified":"2023-06-08T14:02:31","modified_gmt":"2023-06-08T05:02:31","slug":"2023-06-09-jc","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/","title":{"rendered":"Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">We will discuss about \u201cThe energy cost and optimal design of networks for biological discrimination\u201d, Yu, Qiwei, Anatoly B. Kolomeisky, and Oleg A. Igoshin., <i>Journal of the Royal Society Interface<\/i>\u00a019.188 (2022): 20210883.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">Abstract<\/span><\/p>\n<div class=\"hlFld-Abstract\">\n<div class=\"abstractSection abstractInFull\">\n<p>Many biological processes discriminate between correct and incorrect substrates through the kinetic proofreading mechanism that enables lower error at the cost of higher energy dissipation. Elucidating physico-chemical constraints for global minimization of dissipation and error is important for understanding enzyme evolution. Here, we identify theoretically a fundamental error\u2013cost bound that tightly constrains the performance of proofreading networks under any parameter variations preserving the rate discrimination between substrates. The bound is kinetically controlled, i.e. completely determined by the difference between the transition state energies on the underlying free energy landscape. The importance of the bound is analysed for three biological processes. DNA replication by T7 DNA polymerase is shown to be nearly optimized, i.e. its kinetic parameters place it in the immediate proximity of the error\u2013cost bound. The isoleucyl-tRNA synthetase (IleRS) of\u00a0<i>E. coli<\/i>\u00a0also operates close to the bound, but further optimization is prevented by the need for reaction speed. In contrast,\u00a0<i>E. coli<\/i>\u00a0ribosome operates in a high-dissipation regime, potentially in order to speed up protein production. Together, these findings establish a fundamental error\u2013dissipation relation in biological proofreading networks and provide a theoretical framework for studying error\u2013dissipation trade-off in other systems with biological discrimination.<\/p>\n<\/div>\n<\/div>\n<div class=\"clt-dropzone\" data-pb-dropzone=\"clt-dropzone\"><\/div>\n<div class=\"hlFld-Fulltext\">\n<div id=\"acd1e404\" class=\"anchor-spacer\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>We will discuss about \u201cThe energy cost and optimal design of networks for biological discrimination\u201d, Yu, Qiwei, Anatoly B. Kolomeisky, and Oleg A. Igoshin., Journal of the Royal Society Interface\u00a019.188 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination&#8221;<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[219],"class_list":["post-7805","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-journal-club","cat_journal-club"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"We will discuss about \u201cThe energy cost and optimal design of networks for biological discrimination\u201d, Yu, Qiwei, Anatoly B. 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Kolomeisky, and Oleg A. Igoshin., Journal of the Royal Society Interface\u00a019.188 &hellip; Continue reading \"Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination\"","og_url":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/","og_site_name":"Biomedical Mathematics Group","article_modified_time":"2023-06-08T05:02:31+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/","url":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/","name":"Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination - Biomedical Mathematics Group","isPartOf":{"@id":"https:\/\/www.ibs.re.kr\/bimag\/#website"},"datePublished":"2023-05-29T03:23:27+00:00","dateModified":"2023-06-08T05:02:31+00:00","breadcrumb":{"@id":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-06-09-jc\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ibs.re.kr\/bimag\/"},{"@type":"ListItem","position":2,"name":"Events","item":"https:\/\/www.ibs.re.kr\/bimag\/events\/"},{"@type":"ListItem","position":3,"name":"Seokjoo Chae, The energy cost and optimal design of networks for biological discrimination"}]},{"@type":"WebSite","@id":"https:\/\/www.ibs.re.kr\/bimag\/#website","url":"https:\/\/www.ibs.re.kr\/bimag\/","name":"Biomedical Mathematics Group","description":"\uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0 \uc758\uc0dd\uba85\uc218\ud559\uadf8\ub8f9","publisher":{"@id":"https:\/\/www.ibs.re.kr\/bimag\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ibs.re.kr\/bimag\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.ibs.re.kr\/bimag\/#organization","name":"IBS Biomedical Mathematics Group","url":"https:\/\/www.ibs.re.kr\/bimag\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.ibs.re.kr\/bimag\/#\/schema\/logo\/image\/","url":"https:\/\/www.ibs.re.kr\/bimag\/cms\/wp-content\/uploads\/2021\/02\/ibs-circle-1.png","contentUrl":"https:\/\/www.ibs.re.kr\/bimag\/cms\/wp-content\/uploads\/2021\/02\/ibs-circle-1.png","width":250,"height":250,"caption":"IBS Biomedical Mathematics Group"},"image":{"@id":"https:\/\/www.ibs.re.kr\/bimag\/#\/schema\/logo\/image\/"}}]}},"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"dimag-thumbnail":false,"twentyseventeen-featured-image":false,"twentyseventeen-thumbnail-avatar":false},"uagb_author_info":{"display_name":"Hyeontae Jo","author_link":"https:\/\/www.ibs.re.kr\/bimag\/author\/ibs-htj\/"},"uagb_comment_info":0,"uagb_excerpt":"We will discuss about \u201cThe energy cost and optimal design of networks for biological discrimination\u201d, Yu, Qiwei, Anatoly B. 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