{"id":7043,"date":"2022-12-16T07:17:15","date_gmt":"2022-12-15T22:17:15","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&#038;p=7043"},"modified":"2022-12-22T17:27:09","modified_gmt":"2022-12-22T08:27:09","slug":"from-grave-to-cradle-human-somatic-mosaicism-and-unsolved-questions","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/from-grave-to-cradle-human-somatic-mosaicism-and-unsolved-questions\/","title":{"rendered":"Ji Won Oh, From Grave to Cradle: Human Somatic Mosaicism and Unsolved Questions"},"content":{"rendered":"<div class=\"page\" title=\"Page 1\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>\uc0ac\ub78c\uc774 \uc5b4\ub5bb\uac8c \ub9cc\ub4e4\uc5b4\uc9c0\uace0 \uac01 \uae30\uad00\uc774 \uc5b4\ub5bb\uac8c \ubc1c\ub2ec\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uc9c8\ubb38\uc740 \uc544\uc8fc \uc624\ub798\uc804\ubd80\ud130 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uccb4\uc678\uc218\uc815(IVF)\uc758 \uace0\uc720\uc758 \uc7a5\uc810\uc73c\ub85c \uc778\ud574 \uacfc\ud559\uc790\ub4e4\uc774 \uc218\uc815\ub780\uc744 \uc678\ubd80\uc5d0\uc11c \uad00\ucc30\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc, 1979\ub144\ub3c4\uc5d0 \uc81c\uc815\ub41c 14\uc77c \uaddc\uc815(the 14-day rule)\uc73c\ub85c \uc778\ud574, \uc218\uc815 \ud6c4 \ucd5c\ub300 14\uc77c\uae4c\uc9c0\uc758 \ubc30\uc544 \ub9cc\uc758 \uc5f0\uad6c\uac00 \uac00\ub2a5\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c, \uc774 14\uc77c \uaddc\uc815\uc740 \ubc1c\uc0dd \uc0dd\ubb3c\ud559\uc790\ub4e4\uc774 \uc0ac\ub78c \ubc1c\uc0dd\ud559 \uc5f0\uad6c\uc5d0 \uc788\uc5b4\uc11c \uc218\uc815 \ud6c4 2\uc8fc \uc774\uc0c1(\uc2e0\uacbd\uacc4 \ubc1c\ub2ec, \uae30\uad00 \ud615\uc131 \ub4f1)\uc5d0 \ub098\ud0c0\ub098\ub294 \ud604\uc0c1\uc744 \uc5f0\uad6c\ud558\uace0\uc790 \ud560 \uacbd\uc6b0 \ub2e4\ub978 \ubc29\ud5a5\uc744 \ubaa8\uc0c9\ud560 \uc218\ubc16\uc5d0 \uc5c6\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 \uc774 \uc9c0\uc810\uc5d0\uc11c\ubd80\ud130 \uc2dc\uc791\ud569\ub2c8\ub2e4. \uc5f0\uad6c\uc9c4\ub4e4\uc740 \uc138\ud3ec \ubd84\uc5f4 \ub54c \uc6b0\uc5f0\ud788 \ubc1c\uc0dd\ud558\ub294 \uc0dd\ub9ac\ud559\uc801 \uccb4\uc138\ud3ec \ubcc0\uc774(Post-zygotic Variants)\ub97c \ucd94\uc801\ud558\uc5ec \uac01 \uc138\ud3ec\ub4e4\uc758 \uc6b4\uba85\uc744 \uc7ac\uad6c\uc131\ud558\uc600\uc2b5\ub2c8\ub2e4. \ud2b9\ud788 \uc0ac\ub9dd \ud6c4 \uae30\uc99d\ub41c \uc2dc\uc2e0\uc5d0\uc11c \ub2e8\uc77c \uc138\ud3ec\ub97c \ubc30\uc591\ud558\uace0, \ucd5c\uadfc \uac1c\ubc1c\ub41c \ucc28\uc138\ub300 \uc5fc\uae30\uc11c\uc5f4 \ubd84\uc11d \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc778\uac04 \ubc1c\uc0dd \uc5f0\uad6c\uc758 \ud6c4\ud5a5\uc801 \ud608\ud1b5 \ucd94\uc801(Retrospective Lineage Tracing)\uc744 \uc218\ud589\ud558\ub294 \uacfc\uc815\uc744 \ubc1c\ud45c\ud558\uace0\uc790 \ud569\ub2c8\ub2e4. \uc774\ubc88 \ubc1c\ud45c\ub97c \ud1b5\ud574\uc11c \uc774\ub7f0 \ubc29\ubc95\ub860\uc774 \uc5b4\ub5bb\uac8c \uac00\ub2a5\ud588\ub294\uc9c0\uc5d0 \ub300\ud55c \uc0dd\ubb3c\ud559\uc801 \ubc0f \uacfc\ud559\uc801 \ubc30\uacbd\uacfc \uc778\uac04 \ubc1c\uc0dd\ud559\uc758 \ubbf8\ub798\uc5d0\uc11c \ud574\uacb0\ud574\uc57c \ud560 \uacfc\uc81c\uc640 \uac00\uc124\uc744 \uac15\uc870\ud560 \uc608\uc815\uc785\ub2c8\ub2e4. \ucd94\uac00\ub85c, \uc774 \uacfc\uc815\uc5d0\uc11c \ud544\uc694\ud55c \uc218\ud559\uc801\uc778 \ud574\uc11d\uc774 \ud544\uc694\ud55c \uc9c8\ubb38\ub4e4\uc5d0 \ub300\ud574\uc11c\ub3c4 \ub17c\uc758\ud560 \uc608\uc815\uc785\ub2c8\ub2e4. \uc5ec\ub7ec\ubd84\ub4e4\uc758 \ucc38\uc2e0\ud55c \uc2dc\uac01\uacfc \uc9c8\ubb38\uc744 \ud06c\uac8c \ud658\uc601\ud569\ub2c8\ub2e4.<\/p>\n<\/div>\n<div class=\"page\" title=\"Page 1\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>1) Park, S., Mali, N.M., Kim, R. et al. Clonal dynamics in early human embryogenesis inferred from somatic mutation. Nature 597, 393\u2013397 (2021). https:\/\/doi.org\/10.1038\/s41586-021-03786-8<\/p>\n<p>2) Kwon, S.G., Bae, G.H., Choi, J.H. et al. Asymmetric Contribution of Blastomere Lineages of First Division of the Zygote to Entire Human Body Using Post-Zygotic Variants. Tissue Eng Regen Med 19, 809\u2013821 (2022). https:\/\/doi.org\/10.1007\/s13770-022-00443-7<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\uc0ac\ub78c\uc774 \uc5b4\ub5bb\uac8c \ub9cc\ub4e4\uc5b4\uc9c0\uace0 \uac01 \uae30\uad00\uc774 \uc5b4\ub5bb\uac8c \ubc1c\ub2ec\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uc9c8\ubb38\uc740 \uc544\uc8fc \uc624\ub798\uc804\ubd80\ud130 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uccb4\uc678\uc218\uc815(IVF)\uc758 \uace0\uc720\uc758 \uc7a5\uc810\uc73c\ub85c \uc778\ud574 \uacfc\ud559\uc790\ub4e4\uc774 \uc218\uc815\ub780\uc744 \uc678\ubd80\uc5d0\uc11c \uad00\ucc30\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc, 1979\ub144\ub3c4\uc5d0 \uc81c\uc815\ub41c 14\uc77c \uaddc\uc815(the 14-day rule)\uc73c\ub85c &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/from-grave-to-cradle-human-somatic-mosaicism-and-unsolved-questions\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Ji Won Oh, From Grave to Cradle: Human Somatic Mosaicism and Unsolved Questions&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[220],"class_list":["post-7043","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-biomedical-mathematics-seminar","cat_biomedical-mathematics-seminar"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ji Won Oh, From Grave to Cradle: Human Somatic Mosaicism and Unsolved Questions - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/from-grave-to-cradle-human-somatic-mosaicism-and-unsolved-questions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ji Won Oh, From Grave to Cradle: Human Somatic Mosaicism and Unsolved Questions - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"\uc0ac\ub78c\uc774 \uc5b4\ub5bb\uac8c \ub9cc\ub4e4\uc5b4\uc9c0\uace0 \uac01 \uae30\uad00\uc774 \uc5b4\ub5bb\uac8c \ubc1c\ub2ec\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uc9c8\ubb38\uc740 \uc544\uc8fc \uc624\ub798\uc804\ubd80\ud130 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uccb4\uc678\uc218\uc815(IVF)\uc758 \uace0\uc720\uc758 \uc7a5\uc810\uc73c\ub85c \uc778\ud574 \uacfc\ud559\uc790\ub4e4\uc774 \uc218\uc815\ub780\uc744 \uc678\ubd80\uc5d0\uc11c \uad00\ucc30\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc, 1979\ub144\ub3c4\uc5d0 \uc81c\uc815\ub41c 14\uc77c \uaddc\uc815(the 14-day rule)\uc73c\ub85c &hellip; 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