{"id":5593,"date":"2022-04-28T02:00:00","date_gmt":"2022-01-30T04:03:42","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&p=5593"},"modified":"2022-02-24T09:26:39","modified_gmt":"2022-02-24T00:26:39","slug":"2022-04-28","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/2022-04-28\/","title":{"rendered":"Scaling behaviors in physiological fluctuations: relevance to circadian regulation and insights into the development of Alzheimer\u2019s disease"},"content":{"rendered":"

This talk will be presented online. Zoom link: 997 8258 4700<\/a> (pw: 1234)<\/p>\n

Abstract: Outputs from health biological systems display complex fluctuations that are not random but display robust and often self-similar (fractal) temporal correlations at different time scales\u2014 scaling behaviors. The scaling behaviors in the fluctuations of biological outputs such as neural activities, cardiac dynamics, motor activity are believed to be originated from feedbacks within the complex biological networks, reflecting the system adaptability to internal and external inputs. Supporting this concept, our studies have demonstrated a mechanistic link between the scaling regulation of physiological fluctuations and the circadian control system\u2014 a result of evolutionary adaptation to daily environmental light-dark cycles on the earth. In this talk, I will discuss certain evidence for this \u2018scaling-circadian\u2019 link and its related implications. Moreover, I will review some recent studies, in which we examined how the scaling patterns of human motor activity fluctuations change with aging and in Alzheimer\u2019s disease. Our results showed that (1) alterations in scaling activity patterns occur before the clinical manifestation of Alzheimer\u2019s disease (i.e., cognitive impairment) and predict cognitive decline and the risk for Alzheimer\u2019s dementia; and (2) the progression of Alzheimer\u2019s disease accelerates the aging effect on the scaling activity patterns. Our work provides strong evidence that altered scaling activity patterns may also be a risk factor for neurodegeneration, playing a role in the development and progression of Alzheimer\u2019s disease. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

This talk will be presented online. Zoom link: 997 8258 4700 (pw: 1234) Abstract: Outputs from health biological systems display complex fluctuations that are not random but display robust and … <\/p>\n

Continue reading “Scaling behaviors in physiological fluctuations: relevance to circadian regulation and insights into the development of Alzheimer\u2019s disease”<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":5573,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[221],"class_list":["post-5593","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-biomedical-mathematics-colloquium","cat_biomedical-mathematics-colloquium","tribe-ext-events-control-list-event--live"],"yoast_head":"\nScaling behaviors in physiological fluctuations: relevance to circadian regulation and insights into the development of Alzheimer\u2019s disease - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2022-04-28\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scaling behaviors in physiological fluctuations: relevance to circadian regulation and insights into the development of Alzheimer\u2019s disease - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"This talk will be presented online. 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