We will discuss about \u201cThe Oscillation Amplitude, Not the Frequency of Cytosolic Calcium, Regulates Apoptosis Induction \u201d, Qi et al., iScience, 2020<\/p>\n
Abstract:<\/p>\n
Although a rising concentration of cytosolic Ca2+<\/sup>\u00a0has long been recognized as an essential signal for apoptosis, the dynamical mechanisms by which Ca2+<\/sup>\u00a0regulates apoptosis are not clear yet. To address this, we constructed a computational model that integrates known biochemical reactions and can reproduce the dynamical behaviors of Ca2+<\/sup>-induced apoptosis as observed in experiments. Model analysis shows that oscillating Ca2+<\/sup>\u00a0signals first convert into gradual signals and eventually transform into a switch-like apoptotic response. Via the two processes, the apoptotic signaling pathway filters the frequency of Ca2+<\/sup>\u00a0oscillations effectively but instead responds acutely to their amplitude. Collectively, our results suggest that Ca2+<\/sup>\u00a0regulates apoptosis mainly via oscillation amplitude, rather than frequency, modulation. This study not only provides a comprehensive understanding of how oscillatory Ca2+<\/sup>\u00a0dynamically regulates the complex apoptotic signaling network but also presents a typical example of how Ca2+<\/sup>\u00a0controls cellular responses through amplitude modulation.<\/p>\n","protected":false},"excerpt":{"rendered":" We will discuss about \u201cThe Oscillation Amplitude, Not the Frequency of Cytosolic Calcium, Regulates Apoptosis Induction \u201d, Qi et al., iScience, 2020 Abstract: Although a rising concentration of cytosolic Ca2+\u00a0has … <\/p>\n