{"id":4850,"date":"2021-10-07T02:00:00","date_gmt":"2021-08-02T00:08:13","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&p=4850"},"modified":"2021-12-30T12:14:35","modified_gmt":"2021-12-30T03:14:35","slug":"2021-10-07","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-10-07\/","title":{"rendered":"A temporal signaling code to specify immune responses"},"content":{"rendered":"

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234)<\/p>\n

Abstract:<\/p>\n

Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. To generate stimulus-specific gene expression responses, immune sentinel cells have evolved a temporal code in the dynamics of stimulus responsive transcription factors. I will present recent works 1) using an information theoretic approach to identify the codewords, termed \u201csignaling codons\u201d, 2) using a machine learning approach to characterize their reliability and points of confusion, and 3) dynamical systems modeling to characterize the molecular circuits that allow for their encoding. I will present progress on how the temporal code may be decoded to specify immune responses.\u00a0 Further, I will discuss to what extent such a code may be harnessed to achieve greater pharmacological specificity when therapeutically targeting pleiotropic signaling hubs.<\/p>\n

NF\u03baB Signaling: information theory, signaling codons<\/p>\n

Adelaja, A., Taylor, B., Sheu, K.M., Liu, Y., Luecke, S., Hoffmann, A. 2021 Six distinct NF\u03baB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity, 54, pp.916-930. e7. PMID: 33979588<\/p>\n

Tang, Y., Adelaja, A., Ye, X, Deeds, E., Wollman, R., Hoffmann, A. 2021. Quantifying information accumulation encoded in the dynamics of biochemical signaling. Nature Communications 12, pp.1-10<\/p>\n

Decoding signaling codons to specify immune responses<\/p>\n

Sen S., Cheng, Z., Sheu, K., Chen, E.Y.H., Hoffmann, A. 2020 Gene Regulatory Strategies that Decode the Duration of NFkB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression. Cell Systems, 10, pp.1-14. PMID:31972132, PMC7047529<\/a><\/p>\n

Cheng, Q.J., Ohta, S., Sheu, K.M., Spreafico, R., Adelaja, A., Taylor, B., Hoffmann, A.\u00a0 2021 NF\u03baB dynamics determine the stimulus-specificity of epigenomic reprogramming in macrophages. Science, 372, pp.1349-1353; PMID: 34140389.<\/p>\n

Pharmacologic manipulation of the code<\/p>\n

Behar, M., Barken, D., Werner, S.L., Hoffmann, A. 2013\u00a0 The Dynamics of Signaling as a Pharmacological Target.\u00a0 Cell, 155, pp.448-461. PMID: 24120141, PMC3856316<\/p>\n","protected":false},"excerpt":{"rendered":"

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Immune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens … <\/p>\n

Continue reading “A temporal signaling code to specify immune responses”<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":5412,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[221],"class_list":["post-4850","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-biomedical-mathematics-colloquium","cat_biomedical-mathematics-colloquium"],"yoast_head":"\nA temporal signaling code to specify immune responses - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-10-07\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A temporal signaling code to specify immune responses - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"This talk will be presented online. 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