{"id":4787,"date":"2021-11-04T02:00:00","date_gmt":"2021-07-27T07:05:46","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&p=4787"},"modified":"2021-09-30T13:02:22","modified_gmt":"2021-09-30T04:02:22","slug":"2021-10-21","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-10-21\/","title":{"rendered":"Scaling in development"},"content":{"rendered":"
This talk will be presented online. Zoom link: 709 120 4849<\/a> (pw: 1234)<\/div>\n
\n

Abstract:<\/p>\n

\u00a0Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration and has long fascinated scientists. I will first discuss a generic theoretical framework to show how scaling gene expression pattern can emerge from non-scaling morphogen gradients. I will then demonstrate that the Drosophila gap gene system achieves scaling in a way that is entirely consistent with our theory. Remarkably, a parameter-free model based on the theory quantitatively accounts for the gap gene expression pattern in nearly all morphogen mutants. Furthermore, the regulation logic and the coding\/decoding strategy of the gap gene system can be revealed. Our work provides a general theoretical framework on a large class of problems where scaling output is induced by non-scaling input, as well as a unified understanding of scaling, mutants\u2019 behavior and regulation in the Drosophila gap gene and related systems.<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: \u00a0Within a given species, fluctuations in egg or embryo size is unavoidable. Despite this, the gene … <\/p>\n

Continue reading “Scaling in development”<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4788,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[221],"class_list":["post-4787","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-biomedical-mathematics-colloquium","cat_biomedical-mathematics-colloquium"],"yoast_head":"\nScaling in development - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-10-21\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scaling in development - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: \u00a0Within a given species, fluctuations in egg or embryo size is unavoidable. 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Zoom link: 709 120 4849 (pw: 1234) Abstract: \u00a0Within a given species, fluctuations in egg or embryo size is unavoidable. 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