{"id":4754,"date":"2021-07-22T04:00:00","date_gmt":"2021-07-21T11:02:33","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&#038;p=4754"},"modified":"2021-07-26T21:53:53","modified_gmt":"2021-07-26T12:53:53","slug":"2021-07-22","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-22\/","title":{"rendered":"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter"},"content":{"rendered":"<p>We will discuss about \u201cParameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter\u201d, Bonarius <em>et. al.<\/em>, IEEE Trans. Biomed. Eng., 2021<\/p>\n<p>Abstract<\/p>\n<p>Objective: In the near future, real-time estimation of peoples unique, precise circadian clock state has the potential to improve the efficacy of medical treatments and improve human performance on a broad scale. Humancentric lighting can bring circadian-rhythm support using biodynamic lighting solutions that sync light with the time of day. We investigate a method to improve the tracking of individual\u2019s circadian processes. Methods: In literature, the human circadian physiology has been mathematically modeled using ordinary differential equations, the state of which can be tracked via the signal processing concept of a Particle Filter. We show that substantial improvements can be made if the estimator not only tracks state variables, such as the phase and amplitude of the circadian pacemaker, but also fits specific model parameters to the individual. In particular, we optimize model parameter \u03c4x, which reflects the intrinsic period of the circadian pacemaker (\u03c4). We show that both state and model parameters can be estimated based on minimally-invasive light exposure measurements and sleep-wake state observations. We also quantify the effect of inaccuracies in sensing. Results: We demonstrate improved performance by estimating \u03c4x for every individual, both with artificially created and human subject data. Prediction accuracy improves with every newly available observation. The estimated \u03c4x-s correlate well with the subjects\u2019 chronotypes, in a similar way as \u03c4 correlates. Conclusion: Our results show that individualizing the estimation of model parameters can improve circadian state estimation accuracy. Significance: These findings underscore the potential improvements in personalized models over one-size fits all approaches.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We will discuss about \u201cParameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter\u201d, Bonarius et. al., IEEE Trans. Biomed. Eng., 2021 Abstract Objective: In the &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-22\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[219],"class_list":["post-4754","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-journal-club","cat_journal-club"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-22\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"We will discuss about \u201cParameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter\u201d, Bonarius et. al., IEEE Trans. Biomed. Eng., 2021 Abstract Objective: In the &hellip; Continue reading &quot;Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-22\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomedical Mathematics Group\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-26T12:53:53+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/2021-07-22\\\/\",\"url\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/2021-07-22\\\/\",\"name\":\"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter - Biomedical Mathematics Group\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#website\"},\"datePublished\":\"2021-07-21T11:02:33+00:00\",\"dateModified\":\"2021-07-26T12:53:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/2021-07-22\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/2021-07-22\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/2021-07-22\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Events\",\"item\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/events\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#website\",\"url\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/\",\"name\":\"Biomedical Mathematics Group\",\"description\":\"\uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0 \uc758\uc0dd\uba85\uc218\ud559\uadf8\ub8f9\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#organization\",\"name\":\"IBS Biomedical Mathematics Group\",\"url\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/cms\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/ibs-circle-1.png\",\"contentUrl\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/cms\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/ibs-circle-1.png\",\"width\":250,\"height\":250,\"caption\":\"IBS Biomedical Mathematics Group\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter - Biomedical Mathematics Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-22\/","og_locale":"en_US","og_type":"article","og_title":"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter - Biomedical Mathematics Group","og_description":"We will discuss about \u201cParameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter\u201d, Bonarius et. al., IEEE Trans. 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Eng., 2021 Abstract Objective: In the &hellip; Continue reading \"Parameter Estimation in a Model of the Human Circadian Pacemaker Using a Particle Filter\"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/tribe_events\/4754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":3,"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/tribe_events\/4754\/revisions"}],"predecessor-version":[{"id":4757,"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/tribe_events\/4754\/revisions\/4757"}],"wp:attachment":[{"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/media?parent=4754"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/tags?post=4754"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/wp\/v2\/tribe_events_cat?post=4754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}