{"id":4383,"date":"2021-04-07T13:03:01","date_gmt":"2021-04-07T04:03:01","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&#038;p=4383"},"modified":"2021-07-18T08:53:15","modified_gmt":"2021-07-17T23:53:15","slug":"2021-07-28","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-28\/","title":{"rendered":"Theory and design of molecular integral feedback controllers"},"content":{"rendered":"<div class=\"msg-item text _compile ng-scope\">This talk will be presented online. Zoom link: <a href=\"https:\/\/zoom.us\/j\/7091204849#success\">709 120 4849<\/a> (pw: 1234)<\/div>\n<div>Abstract:<\/p>\n<div>Homeostasis is a recurring theme in biology that ensures that regulated variables robustly adapt to environmental perturbations. This robust perfect adaptation feature is achieved in natural circuits by using integral control, a negative feedback strategy that performs mathematical integration to achieve structurally robust regulation. Despite its benefits, the synthetic realization of integral feedback in living cells has remained elusive owing to the complexity of the required biological computations. In this talk I will show that there is a single fundamental biomolecular controller topology\u00a0that realizes integral feedback and achieves robust perfect adaptation in arbitrary intracellular networks with noisy dynamics. This adaptation property is guaranteed both for the population-average and for the time-average of single cells. On\u00a0the basis of this concept, I will describe a genetically engineered synthetic integral feedback controller in living cells\u00a0and demonstrate its tunability and adaptation properties. A growth-rate control application in\u00a0<i>Escherichia coli<\/i>\u00a0shows the intrinsic capacity of our integral controller to deliver robustness and highlights its potential use as a versatile controller for regulation of biological variables in uncertain networks. These results provide conceptual and practical tools in the area of cybergenetics, for engineering synthetic controllers that steer the dynamics of living systems.<\/div>\n<\/div>\n<div class=\"msg-extra\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) Abstract: Homeostasis is a recurring theme in biology that ensures that regulated variables robustly adapt to environmental &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-28\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Theory and design of molecular integral feedback controllers&#8221;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":4384,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[221],"class_list":["post-4383","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-biomedical-mathematics-colloquium","cat_biomedical-mathematics-colloquium","tribe-ext-events-control-list-event--live"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Theory and design of molecular integral feedback controllers - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/2021-07-28\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Theory and design of molecular integral feedback controllers - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"This talk will be presented online. 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