{"id":11754,"date":"2025-10-04T15:41:51","date_gmt":"2025-10-04T06:41:51","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&#038;p=11754"},"modified":"2025-10-23T12:51:54","modified_gmt":"2025-10-23T03:51:54","slug":"dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\/","title":{"rendered":"Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology &#8211; Chitaranjan Mahapatra"},"content":{"rendered":"<p>In this talk, we discuss the paper &#8220;Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology&#8221; by <span class=\"authors-list-item \">Ning Wei and<span class=\"comma\">\u00a0<\/span><\/span><span class=\"authors-list-item \">Casey O Diekman, J. Biol. Rhythms, 2025.\u00a0<\/span><\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Circadian clocks regulate many aspects of human physiology, including cardiovascular function and drug metabolism. Administering drugs at optimal times of the day may enhance effectiveness and reduce side effects. Certain cardiac antiarrhythmic drugs have been withdrawn from the market due to unexpected proarrhythmic effects such as fatal Torsade de Pointes (TdP) ventricular tachycardia. The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a recent global initiative to create guidelines for the assessment of drug-induced arrhythmias that recommends a central role for computational modeling of ion channels and\u00a0<i>in silico<\/i>\u00a0evaluation of compounds for TdP risk. We simulated circadian regulation of cardiac excitability and explored how dosing time of day affects TdP risk for 11 drugs previously classified into risk categories by CiPA. The model predicts that a high-risk drug taken at the most optimal time of day may actually be safer than a low-risk drug taken at the least optimal time of day. Based on these proof-of-concept results, we advocate for the incorporation of circadian clock modeling into the CiPA paradigm for assessing drug-induced TdP risk. Since cardiotoxicity is the leading cause of drug discontinuation, modeling cardiac-related chronopharmacology has significant potential to improve therapeutic outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this talk, we discuss the paper &#8220;Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology&#8221; by Ning Wei and\u00a0Casey O Diekman, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology &#8211; Chitaranjan Mahapatra&#8221;<\/span><\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[219],"class_list":["post-11754","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-journal-club","cat_journal-club"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology - Chitaranjan Mahapatra - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology - Chitaranjan Mahapatra - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"In this talk, we discuss the paper &#8220;Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology&#8221; by Ning Wei and\u00a0Casey O Diekman, &hellip; Continue reading &quot;Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology &#8211; Chitaranjan Mahapatra&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ibs.re.kr\/bimag\/event\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomedical Mathematics Group\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-23T03:51:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\\\/\",\"url\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\\\/\",\"name\":\"Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology - Chitaranjan Mahapatra - Biomedical Mathematics Group\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/#website\"},\"datePublished\":\"2025-10-04T06:41:51+00:00\",\"dateModified\":\"2025-10-23T03:51:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/event\\\/dosing-time-of-day-impacts-the-safety-of-antiarrhythmic-drugs-in-a-computational-model-of-cardiac-electrophysiology-chitaranjan-mahapatra\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Events\",\"item\":\"https:\\\/\\\/www.ibs.re.kr\\\/bimag\\\/events\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology &#8211; 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