{"id":11368,"date":"2025-08-04T10:03:21","date_gmt":"2025-08-04T01:03:21","guid":{"rendered":"https:\/\/www.ibs.re.kr\/bimag\/?post_type=tribe_events&p=11368"},"modified":"2025-08-24T13:11:10","modified_gmt":"2025-08-24T04:11:10","slug":"jooyoung-hahn-topological-data-analysis-with-two-applications-tumor-microenvironment-and-2d-chromatography-with-high-resolution-mass-spectrometry","status":"publish","type":"tribe_events","link":"https:\/\/www.ibs.re.kr\/bimag\/event\/jooyoung-hahn-topological-data-analysis-with-two-applications-tumor-microenvironment-and-2d-chromatography-with-high-resolution-mass-spectrometry\/","title":{"rendered":"Jooyoung Hahn – Topological Data Analysis with two applications: Tumor Microenvironment and 2D Chromatography with High-Resolution Mass Spectrometry"},"content":{"rendered":"

Abstract\u00a0<\/strong><\/p>\n

Topological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional, complex datasets. In this talk, we present\u00a0two\u00a0applications\u00a0of TDA in analyzing patterns, one in the tumor microenvironment (TME) and the other in high-resolution chemical profiling. In the first case, we develop a TDA-based framework to quantify malignant-immune cell interactions in Diffuse Large B Cell Lymphoma using multiplex immunofluorescence imaging. By introducing\u00a0Topological Malignant Clusters<\/em>\u00a0(TopMC) and leveraging persistence diagrams, we capture\u00a0both\u00a0global infiltration patterns and local density-based features. This robust approach enables consistent prognostic assessment regardless of tumor region heterogeneity and reveals correlations with patient survival. In the second\u00a0application, we utilize the\u00a0Ball Mapper<\/em>\u00a0algorithm to simplify and visualize high-dimensional data obtained from 2D Chromatography with high-resolution mass spectrometry. This enables interpretable chemical profiling of complex mixtures and supports tasks such as sample authentication and environmental analysis. Together, these studies demonstrate the versatility and interpretability of TDA for extracting biologically and chemically meaningful information.<\/p>\n

Seminar Video Link: https:\/\/www.youtube.com\/watch?v=mz9pY6nk3n4&t=12s<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Abstract\u00a0 Topological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional, complex datasets. In this talk, we present\u00a0two\u00a0applications\u00a0of TDA in analyzing patterns, one in … <\/p>\n

Continue reading “Jooyoung Hahn – Topological Data Analysis with two applications: Tumor Microenvironment and 2D Chromatography with High-Resolution Mass Spectrometry”<\/span><\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_uag_custom_page_level_css":"","_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[220],"class_list":["post-11368","tribe_events","type-tribe_events","status-publish","hentry","tribe_events_cat-biomedical-mathematics-seminar","cat_biomedical-mathematics-seminar"],"yoast_head":"\nJooyoung Hahn - Topological Data Analysis with two applications: Tumor Microenvironment and 2D Chromatography with High-Resolution Mass Spectrometry - Biomedical Mathematics Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ibs.re.kr\/bimag\/event\/jooyoung-hahn-topological-data-analysis-with-two-applications-tumor-microenvironment-and-2d-chromatography-with-high-resolution-mass-spectrometry\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jooyoung Hahn - Topological Data Analysis with two applications: Tumor Microenvironment and 2D Chromatography with High-Resolution Mass Spectrometry - Biomedical Mathematics Group\" \/>\n<meta property=\"og:description\" content=\"Abstract\u00a0 Topological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional, complex datasets. 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