{"id":9960,"global_id":"www.ibs.re.kr\/bimag?id=9960","global_id_lineage":["www.ibs.re.kr\/bimag?id=9960"],"author":"11","status":"publish","date":"2024-08-27 09:20:08","date_utc":"2024-08-27 00:20:08","modified":"2024-10-02 09:17:29","modified_utc":"2024-10-02 00:17:29","url":"https:\/\/www.ibs.re.kr\/bimag\/event\/dongju-lim-analysis-of-a-detailed-multi-stage-model-of-stochastic-gene-expression-using-queueing-theory-and-model-reduction\/","rest_url":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/events\/9960","title":"Dongju Lim, Mathematical model for the distribution of DNA replication origins","description":"

In this talk we discuss the paper “Mathematical model for the distribution of DNA replication origins” by Alessandro<\/span>\u00a0de Moura and<\/span><\/span>\u00a0Jens<\/span>\u00a0Karschau<\/span><\/span>, Physical Review E, 2024.<\/p>\n

Abstract\u00a0<\/strong><\/p>\n

DNAreplication in yeast and in many other organisms starts from well-defined locations on the DNA known as replication origins. The spatial distribution of these origins in the genome is particularly important in ensuring that replication is completed quickly. Cells are more vulnerable to DNA damage and other forms of stress while they are replicating their genome. This raises the possibility that the spatial distribution of origins is under selection pressure. In this paper we investigate the hypothesis that natural selection favors origin distributions leading to shorter replication times. Using a simple mathematical model, we show that this hypothesis leads to two main predictions about the origin distributions: that neighboring origins that are inefficient (less likely to fire) are more likely to be close to each other than efficient origins; and that neighboring origins with larger differences in firing times are more likely to be close to each other than origins with similar firing times. We test these predictions using next-generation sequencing data, and show that they are both supported by the data.<\/p>","excerpt":"","slug":"dongju-lim-analysis-of-a-detailed-multi-stage-model-of-stochastic-gene-expression-using-queueing-theory-and-model-reduction","image":false,"all_day":false,"start_date":"2024-10-04 14:00:00","start_date_details":{"year":"2024","month":"10","day":"04","hour":"14","minutes":"00","seconds":"00"},"end_date":"2024-10-04 16:00:00","end_date_details":{"year":"2024","month":"10","day":"04","hour":"16","minutes":"00","seconds":"00"},"utc_start_date":"2024-10-04 05:00:00","utc_start_date_details":{"year":"2024","month":"10","day":"04","hour":"05","minutes":"00","seconds":"00"},"utc_end_date":"2024-10-04 07:00:00","utc_end_date_details":{"year":"2024","month":"10","day":"04","hour":"07","minutes":"00","seconds":"00"},"timezone":"Asia\/Seoul","timezone_abbr":"KST","cost":"","cost_details":{"currency_symbol":"$","currency_code":"USD","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Journal Club","slug":"journal-club","term_group":0,"term_taxonomy_id":219,"taxonomy":"tribe_events_cat","description":"","parent":231,"count":209,"filter":"raw","id":219,"urls":{"self":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/219","collection":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories","up":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/231"}}],"tags":[],"venue":{"id":7007,"author":"3","status":"publish","date":"2022-12-11 21:14:12","date_utc":"2022-12-11 12:14:12","modified":"2022-12-11 21:14:12","modified_utc":"2022-12-11 12:14:12","url":"https:\/\/www.ibs.re.kr\/bimag\/venue\/b232-seminar-room-ibs\/","venue":"B232 Seminar Room, IBS","slug":"b232-seminar-room-ibs","address":"55 Expo-ro Yuseong-gu","city":"Daejeon","country":"Korea, Republic of","province":"Daejeon","zip":"34126","website":"https:\/\/www.ibs.re.kr","stateprovince":"Daejeon","json_ld":{"@type":"Place","name":"B232 Seminar Room, IBS","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"55 Expo-ro Yuseong-gu","addressLocality":"Daejeon","addressRegion":"Daejeon","postalCode":"34126","addressCountry":"Korea, Republic of"},"telephone":"","sameAs":"https:\/\/www.ibs.re.kr"},"show_map":true,"show_map_link":true,"global_id":"www.ibs.re.kr\/bimag?id=7007","global_id_lineage":["www.ibs.re.kr\/bimag?id=7007"]},"organizer":[{"id":3971,"author":"3","status":"publish","date":"2021-02-23 18:10:12","date_utc":"2021-02-23 09:10:12","modified":"2021-02-23 18:10:12","modified_utc":"2021-02-23 09:10:12","url":"https:\/\/www.ibs.re.kr\/bimag\/organizer\/jae-kyoung-kim\/","organizer":"Jae Kyoung Kim","slug":"jae-kyoung-kim","email":"jaekkim@kaist.ac.kr","json_ld":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"global_id":"www.ibs.re.kr\/bimag?id=3971","global_id_lineage":["www.ibs.re.kr\/bimag?id=3971"]}],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Dongju Lim, Mathematical model for the distribution of DNA replication origins","description":"<p>In this talk we discuss the paper "Mathematical model for the distribution of DNA replication origins" by Alessandro\u00a0de Moura and\u00a0Jens\u00a0Karschau, Physical Review E, 2024. Abstract\u00a0 DNAreplication in yeast and in … <\/p>\\n<p class="link-more"><a href="https:\/\/www.ibs.re.kr\/bimag\/event\/dongju-lim-analysis-of-a-detailed-multi-stage-model-of-stochastic-gene-expression-using-queueing-theory-and-model-reduction\/" class="more-link">Continue reading<span class="screen-reader-text"> "Dongju Lim, Mathematical model for the distribution of DNA replication origins"<\/span><\/a><\/p>\\n","url":"https:\/\/www.ibs.re.kr\/bimag\/event\/dongju-lim-analysis-of-a-detailed-multi-stage-model-of-stochastic-gene-expression-using-queueing-theory-and-model-reduction\/","eventAttendanceMode":"https:\/\/schema.org\/OfflineEventAttendanceMode","eventStatus":"https:\/\/schema.org\/EventScheduled","startDate":"2024-10-04T14:00:00+09:00","endDate":"2024-10-04T16:00:00+09:00","location":{"@type":"Place","name":"B232 Seminar Room, IBS","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"55 Expo-ro Yuseong-gu","addressLocality":"Daejeon","addressRegion":"Daejeon","postalCode":"34126","addressCountry":"Korea, Republic of"},"telephone":"","sameAs":"https:\/\/www.ibs.re.kr"},"organizer":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"performer":"Organization"}}