In this talk, we discuss the paper, “MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data” by Siyao Liu et.al.\u00a0 Genome Biology, 2024.<\/p>\n
Abstract\u00a0<\/strong><\/p>\n Single-cell RNA sequencing (scRNA-seq) provides new opportunities to characterize cell populations, typically accomplished through some type of clustering analysis. Estimation of the optimal cluster number (K<\/i>) is a crucial step but often ignored. Our approach improves most current scRNA-seq cluster methods by providing an objective estimation of the number of groups using a multi-resolution perspective. MultiK is a tool for objective selection of insightful\u00a0Ks<\/i>\u00a0and achieves high robustness through a consensus clustering approach. We demonstrate that MultiK identifies reproducible groups in scRNA-seq data, thus providing an objective means to estimating the number of possible groups or cell-type populations present.<\/p>\n <\/p>","excerpt":"","slug":"hyun-kim-powerful-and-accurate-detection-of-temporal-gene-expression-patterns-from-multi-sample-multi-stage-single-cell-transcriptomics-data-with-tdeseq","image":false,"all_day":false,"start_date":"2024-06-14 14:00:00","start_date_details":{"year":"2024","month":"06","day":"14","hour":"14","minutes":"00","seconds":"00"},"end_date":"2024-06-14 16:00:00","end_date_details":{"year":"2024","month":"06","day":"14","hour":"16","minutes":"00","seconds":"00"},"utc_start_date":"2024-06-14 05:00:00","utc_start_date_details":{"year":"2024","month":"06","day":"14","hour":"05","minutes":"00","seconds":"00"},"utc_end_date":"2024-06-14 07:00:00","utc_end_date_details":{"year":"2024","month":"06","day":"14","hour":"07","minutes":"00","seconds":"00"},"timezone":"Asia\/Seoul","timezone_abbr":"KST","cost":"","cost_details":{"currency_symbol":"$","currency_code":"USD\t\t\t\t\t\t\tclass=\t\t\t\t\t\t\tclass=\t\t\t\t\t\t\tclass=","currency_position":"prefix","values":[]},"website":"","show_map":true,"show_map_link":true,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Journal Club","slug":"journal-club","term_group":0,"term_taxonomy_id":219,"taxonomy":"tribe_events_cat","description":"","parent":231,"count":209,"filter":"raw","id":219,"urls":{"self":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/219","collection":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories","up":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/231"}}],"tags":[],"venue":[],"organizer":[{"id":3971,"author":"3","status":"publish","date":"2021-02-23 18:10:12","date_utc":"2021-02-23 09:10:12","modified":"2021-02-23 18:10:12","modified_utc":"2021-02-23 09:10:12","url":"https:\/\/www.ibs.re.kr\/bimag\/organizer\/jae-kyoung-kim\/","organizer":"Jae Kyoung Kim","slug":"jae-kyoung-kim","email":"jaekkim@kaist.ac.kr","json_ld":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"global_id":"www.ibs.re.kr\/bimag?id=3971","global_id_lineage":["www.ibs.re.kr\/bimag?id=3971"]}],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Hyun Kim, MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing datamics data with TDEseq","description":"<p>In this talk, we discuss the paper, "MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing data" by Siyao Liu et.al.\u00a0 Genome Biology, 2024. Abstract\u00a0 Single-cell … <\/p>\\n<p class="link-more"><a href="https:\/\/www.ibs.re.kr\/bimag\/event\/hyun-kim-powerful-and-accurate-detection-of-temporal-gene-expression-patterns-from-multi-sample-multi-stage-single-cell-transcriptomics-data-with-tdeseq\/" class="more-link">Continue reading<span class="screen-reader-text"> "Hyun Kim, MultiK: an automated tool to determine optimal cluster numbers in single-cell RNA sequencing datamics data with TDEseq"<\/span><\/a><\/p>\\n","url":"https:\/\/www.ibs.re.kr\/bimag\/event\/hyun-kim-powerful-and-accurate-detection-of-temporal-gene-expression-patterns-from-multi-sample-multi-stage-single-cell-transcriptomics-data-with-tdeseq\/","eventAttendanceMode":"https:\/\/schema.org\/OfflineEventAttendanceMode","eventStatus":"https:\/\/schema.org\/EventScheduled","startDate":"2024-06-14T14:00:00+09:00","endDate":"2024-06-14T16:00:00+09:00","organizer":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"performer":"Organization"}}