We will discuss about \u201cThe effect of microRNA on protein variability and gene expression fidelity\u201d, Hilfinger, Andreas, and Raymond Fan., Biophysical journal<\/i>\u00a0122.3 (2023): 537a.<\/p>\n
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Small regulatory RNA molecules such as microRNA modulate gene expression through inhibiting the translation of messenger RNA (mRNA). Such post-transcriptional regulation has been recently hypothesized to reduce the stochastic variability of gene expression around average levels. Here we quantify noise in stochastic gene expression models with and without such regulation. Our results suggest that silencing mRNA post-transcriptionally will always increase rather than decrease gene expression noise when the silencing of mRNA also increases its degradation as is expected for microRNA interactions with mRNA. In that regime we also find that silencing mRNA generally reduces the fidelity of signal transmission from deterministically varying upstream factors to protein levels. These findings suggest that microRNA binding to mRNA does not generically confer precision to protein expression<\/div>\n<\/div>","excerpt":"","slug":"2023-03-24-jc","image":false,"all_day":false,"start_date":"2023-03-24 14:00:00","start_date_details":{"year":"2023","month":"03","day":"24","hour":"14","minutes":"00","seconds":"00"},"end_date":"2023-03-24 16:00:00","end_date_details":{"year":"2023","month":"03","day":"24","hour":"16","minutes":"00","seconds":"00"},"utc_start_date":"2023-03-24 05:00:00","utc_start_date_details":{"year":"2023","month":"03","day":"24","hour":"05","minutes":"00","seconds":"00"},"utc_end_date":"2023-03-24 07:00:00","utc_end_date_details":{"year":"2023","month":"03","day":"24","hour":"07","minutes":"00","seconds":"00"},"timezone":"Asia\/Seoul","timezone_abbr":"KST","cost":"","cost_details":{"currency_symbol":"","currency_code":"","currency_position":"prefix","values":[]},"website":"","show_map":true,"show_map_link":true,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Journal Club","slug":"journal-club","term_group":0,"term_taxonomy_id":219,"taxonomy":"tribe_events_cat","description":"","parent":231,"count":209,"filter":"raw","id":219,"urls":{"self":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/219","collection":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories","up":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/231"}}],"tags":[],"venue":{"id":5070,"author":"3","status":"publish","date":"2021-10-01 15:24:54","date_utc":"2021-10-01 06:24:54","modified":"2021-10-01 15:24:54","modified_utc":"2021-10-01 06:24:54","url":"https:\/\/www.ibs.re.kr\/bimag\/venue\/b378-seminar-room-ibs\/","venue":"B378 Seminar room, IBS","slug":"b378-seminar-room-ibs","address":"55 Expo-ro Yuseong-gu","city":"Daejeon","country":"Korea, Republic of","zip":"34126","json_ld":{"@type":"Place","name":"B378 Seminar room, IBS","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"55 Expo-ro Yuseong-gu","addressLocality":"Daejeon","postalCode":"34126","addressCountry":"Korea, Republic of"},"telephone":"","sameAs":""},"show_map":true,"show_map_link":true,"global_id":"www.ibs.re.kr\/bimag?id=5070","global_id_lineage":["www.ibs.re.kr\/bimag?id=5070"]},"organizer":[{"id":3971,"author":"3","status":"publish","date":"2021-02-23 18:10:12","date_utc":"2021-02-23 09:10:12","modified":"2021-02-23 18:10:12","modified_utc":"2021-02-23 09:10:12","url":"https:\/\/www.ibs.re.kr\/bimag\/organizer\/jae-kyoung-kim\/","organizer":"Jae Kyoung Kim","slug":"jae-kyoung-kim","email":"jaekkim@kaist.ac.kr","json_ld":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"global_id":"www.ibs.re.kr\/bimag?id=3971","global_id_lineage":["www.ibs.re.kr\/bimag?id=3971"]}],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Candan Celik, The effect of microRNA on protein variability and gene expression fidelity","description":"<p>We will discuss about \u201cThe effect of microRNA on protein variability and gene expression fidelity\u201d, Hilfinger, Andreas, and Raymond Fan., Biophysical journal\u00a0122.3 (2023): 537a. Abstract Small regulatory RNA molecules such … <\/p>\\n<p class="link-more"><a href="https:\/\/www.ibs.re.kr\/bimag\/event\/2023-03-24-jc\/" class="more-link">Continue reading<span class="screen-reader-text"> "Candan Celik, The effect of microRNA on protein variability and gene expression fidelity"<\/span><\/a><\/p>\\n","url":"https:\/\/www.ibs.re.kr\/bimag\/event\/2023-03-24-jc\/","eventAttendanceMode":"https:\/\/schema.org\/OfflineEventAttendanceMode","eventStatus":"https:\/\/schema.org\/EventScheduled","startDate":"2023-03-24T14:00:00+09:00","endDate":"2023-03-24T16:00:00+09:00","location":{"@type":"Place","name":"B378 Seminar room, IBS","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"55 Expo-ro Yuseong-gu","addressLocality":"Daejeon","postalCode":"34126","addressCountry":"Korea, Republic of"},"telephone":"","sameAs":""},"organizer":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"performer":"Organization"}}