We will discuss about “Identifying the critical states of complex diseases by the dynamic change of multivariate distribution”, Peng, Hao, et al., Briefings in Bioinformatics<\/i>, 2022.<\/p>\n
Abstract: The dynamics of complex diseases are not always smooth; they are occasionally abrupt, i.e. there is a critical state transition or tipping point at which the disease undergoes a sudden qualitative shift. There are generally a few significant differences in the critical state in terms of gene expressions or other static measurements, which may lead to the failure of traditional differential expression-based biomarkers to identify such a tipping point. In this study, we propose a computational method, the direct interaction network-based divergence, to detect the critical state of complex diseases by exploiting the dynamic changes in multivariable distributions inferred from observable samples and local biomolecular direct interaction networks. Such a method is model-free and applicable to both bulk and single-cell expression data. Our approach was validated by successfully identifying the tipping point just before the occurrence of a critical transition for both a simulated data set and seven real data sets, including those from The Cancer Genome Atlas and two single-cell RNA-sequencing data sets of cell differentiation. Functional and pathway enrichment analyses also validated the computational results from the perspectives of both molecules and networks.<\/p>","excerpt":"","slug":"2022-06-16-jc-2","image":false,"all_day":false,"start_date":"2022-06-16 13:00:00","start_date_details":{"year":"2022","month":"06","day":"16","hour":"13","minutes":"00","seconds":"00"},"end_date":"2022-06-16 14:00:00","end_date_details":{"year":"2022","month":"06","day":"16","hour":"14","minutes":"00","seconds":"00"},"utc_start_date":"2022-06-16 04:00:00","utc_start_date_details":{"year":"2022","month":"06","day":"16","hour":"04","minutes":"00","seconds":"00"},"utc_end_date":"2022-06-16 05:00:00","utc_end_date_details":{"year":"2022","month":"06","day":"16","hour":"05","minutes":"00","seconds":"00"},"timezone":"Asia\/Seoul","timezone_abbr":"KST","cost":"","cost_details":{"currency_symbol":"","currency_code":"","currency_position":"prefix","values":[]},"website":"","show_map":true,"show_map_link":true,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Journal Club","slug":"journal-club","term_group":0,"term_taxonomy_id":219,"taxonomy":"tribe_events_cat","description":"","parent":231,"count":209,"filter":"raw","id":219,"urls":{"self":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/219","collection":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories","up":"https:\/\/www.ibs.re.kr\/bimag\/wp-json\/tribe\/events\/v1\/categories\/231"}}],"tags":[],"venue":{"id":5070,"author":"3","status":"publish","date":"2021-10-01 15:24:54","date_utc":"2021-10-01 06:24:54","modified":"2021-10-01 15:24:54","modified_utc":"2021-10-01 06:24:54","url":"https:\/\/www.ibs.re.kr\/bimag\/venue\/b378-seminar-room-ibs\/","venue":"B378 Seminar room, IBS","slug":"b378-seminar-room-ibs","address":"55 Expo-ro Yuseong-gu","city":"Daejeon","country":"Korea, Republic of","zip":"34126","json_ld":{"@type":"Place","name":"B378 Seminar room, IBS","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"55 Expo-ro Yuseong-gu","addressLocality":"Daejeon","postalCode":"34126","addressCountry":"Korea, Republic of"},"telephone":"","sameAs":""},"show_map":true,"show_map_link":true,"global_id":"www.ibs.re.kr\/bimag?id=5070","global_id_lineage":["www.ibs.re.kr\/bimag?id=5070"]},"organizer":[{"id":3971,"author":"3","status":"publish","date":"2021-02-23 18:10:12","date_utc":"2021-02-23 09:10:12","modified":"2021-02-23 18:10:12","modified_utc":"2021-02-23 09:10:12","url":"https:\/\/www.ibs.re.kr\/bimag\/organizer\/jae-kyoung-kim\/","organizer":"Jae Kyoung Kim","slug":"jae-kyoung-kim","email":"jaekkim@kaist.ac.kr","json_ld":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"global_id":"www.ibs.re.kr\/bimag?id=3971","global_id_lineage":["www.ibs.re.kr\/bimag?id=3971"]}],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Identifying the critical states of complex diseases by the dynamic change of multivariate distribution","description":"<p>We will discuss about "Identifying the critical states of complex diseases by the dynamic change of multivariate distribution", Peng, Hao, et al., Briefings in Bioinformatics, 2022. Abstract: The dynamics of … <\/p>\\n<p class="link-more"><a href="https:\/\/www.ibs.re.kr\/bimag\/event\/2022-06-16-jc-2\/" class="more-link">Continue reading<span class="screen-reader-text"> "Identifying the critical states of complex diseases by the dynamic change of multivariate distribution"<\/span><\/a><\/p>\\n","url":"https:\/\/www.ibs.re.kr\/bimag\/event\/2022-06-16-jc-2\/","eventAttendanceMode":"https:\/\/schema.org\/OfflineEventAttendanceMode","eventStatus":"https:\/\/schema.org\/EventScheduled","startDate":"2022-06-16T13:00:00+09:00","endDate":"2022-06-16T14:00:00+09:00","location":{"@type":"Place","name":"B378 Seminar room, IBS","description":"","url":"","address":{"@type":"PostalAddress","streetAddress":"55 Expo-ro Yuseong-gu","addressLocality":"Daejeon","postalCode":"34126","addressCountry":"Korea, Republic of"},"telephone":"","sameAs":""},"organizer":{"@type":"Person","name":"Jae Kyoung Kim","description":"","url":"","telephone":"","email":"jaekkim@kaist.ac.kr","sameAs":""},"performer":"Organization"}}