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X-WR-CALDESC:Events for Biomedical Mathematics Group
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DTSTART:20250101T000000
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DTSTART;TZID=Asia/Seoul:20260626T100000
DTEND;TZID=Asia/Seoul:20260626T120000
DTSTAMP:20260528T215305
CREATED:20260528T012227Z
LAST-MODIFIED:20260528T012227Z
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SUMMARY:Learning Longitudinal Health Representations from EHR and Wearable Data - Hyunji Jeong
DESCRIPTION:In this talk\, we discuss the paper “Learning Longitudinal Health Representations from EHR and Wearable Data” by Yuanyun Zhang et al.\, arXiv\, 2026. \nAbstract: \nFoundation models trained on electronic health records show strong performance on many clinical prediction tasks but are limited by sparse and irregular documentation. Wearable devices provide dense continuous physiological signals but lack semantic grounding. Existing methods usually model these data sources separately or combine them through late fusion. We propose a multimodal foundation model that jointly represents electronic health records and wearable data as a continuous time latent process. The model uses modality specific encoders and a shared temporal backbone pretrained with self supervised and cross modal objectives. This design produces representations that are temporally coherent and clinically grounded. Across forecasting physiological and risk modeling tasks the model outperforms strong electronic health record only and wearable only baselines especially at long horizons and under missing data. These results show that joint electronic health record and wearable pretraining yields more faithful representations of longitudinal health.
URL:https://www.ibs.re.kr/bimag/event/learning-longitudinal-health-representations-from-ehr-and-wearable-data-hyunji-jeong/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20260703T100000
DTEND;TZID=Asia/Seoul:20260703T120000
DTSTAMP:20260528T215305
CREATED:20260527T140141Z
LAST-MODIFIED:20260528T012333Z
UID:12539-1783072800-1783080000@www.ibs.re.kr
SUMMARY:A Metabolism-Informed Neural Network Identifies Pathways Influencing the Potency and Toxicity of Antimicrobial Combinations - Se Jun Ahn
DESCRIPTION:In this talk\, we discuss the paper “A Metabolism-Informed Neural Network Identifies Pathways Influencing the Potency and Toxicity of Antimicrobial Combinations” by Harkirat Sigh Arora et al.\, npj drug discovery\, 2026. \nAbstract: \nAntimicrobial resistance poses a major global threat\, driven by diminishing efficacy of current treatments and limited new therapies. Combination therapy with existing drugs offers a promising solution\, yet current empirical screening methods are expensive and often lead to suboptimal efficacy and inadvertent toxicity. We introduce CALMA\, a computational framework that quantitatively analyzes the potency-toxicity landscape of multi-drug combinations. Integrating genome-scale metabolic modeling with a neural network that reflects metabolic subsystems\, CALMA enhances interpretability and prioritizes pathways influencing drug interactions. The incorporation of metabolic architecture in the neural network leads to over 92% reduction in model parameters\, enabling it to learn generalizable mechanistic signals and reducing the experimental search space of optimal combinations by 97%. CALMA identified promising antimicrobial combinations against Escherichia coli and Mycobacterium tuberculosis that were antagonistic for kidney and liver toxicity and uncovered the nucleotide salvage pathway as a selective influencer of toxicity\, which was validated in vitro. Mining of health records of over 400\,000 patients showed reduced frequency of kidney side-effects in patients taking a vancomycin combination identified by CALMA. CALMA provides a rational\, mechanistic approach to streamline combination treatment design.
URL:https://www.ibs.re.kr/bimag/event/a-metabolism-informed-neural-network-identifies-pathways-influencing-the-potency-and-toxicity-of-antimicrobial-combinations-se-jun-ahn/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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