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METHOD:PUBLISH
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20240101T000000
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END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20251015T160000
DTEND;TZID=Asia/Seoul:20251015T170000
DTSTAMP:20260422T114402
CREATED:20250826T003811Z
LAST-MODIFIED:20250826T003811Z
UID:11464-1760544000-1760547600@www.ibs.re.kr
SUMMARY:Developing time-series machine learning methods to unlock new insights from large-scale biomedical resources - Aiden Doherty
DESCRIPTION:Abstract \nSmartphones and wearable devices provide a major opportunity to transform our understanding of the mechanisms\, determinants\, and consequences of diseases. For example\, around 9 in 10 people own a smartphone in the United Kingdom\, while one-fifth of US adults own wearable technologies. This high level of device ownership means that many people could contribute to health research from the comfort of their home by offering small amounts of time to share data and help address health-related questions that matter to them. A leading example is the seven day wrist-worn accelerometer data measured in 100\,000 UK Biobank participants between 2013-2015 that has led to important new findings. These include discoveries of: new genetic variants for sleep and activity; small amounts of vigorous non-exercise physical activity being associated with substantially lower mortality; and no apparent upper threshold to the benefits of physical activity with respect to cardiovascular disease risk. However\, challenges exist around cost\, access\, validity\, and training. In this talk I will review progress made in this exciting new area of health data science and share opportunities for self-supervised time-series machine learning to provide new insights into physical activity\, sleep\, heart rhythms and other exposures relevant to health and disease.
URL:https://www.ibs.re.kr/bimag/event/developing-time-series-machine-learning-methods-to-unlock-new-insights-from-large-scale-biomedical-resources-aiden-doherty/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/webp:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/08/Aiden-Doherty-e1756168683328.webp
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20251001T160000
DTEND;TZID=Asia/Seoul:20251001T170000
DTSTAMP:20260422T114402
CREATED:20250826T003244Z
LAST-MODIFIED:20250922T073504Z
UID:11458-1759334400-1759338000@www.ibs.re.kr
SUMMARY:Topological Data Analysis for Multiscale Biology - Heather Harrington
DESCRIPTION:Abstract \nMany processes in the life sciences are inherently multi-scale and dynamic. Spatial structures and patterns vary across levels of organisation\, from molecular to multi-cellular to multi-organism. With more sophisticated mechanistic models and data available\, quantitative tools are needed to study their evolution in space and time. Topological data analysis (TDA) provides a multi-scale summary of data. I will review the main tools in topological data analysis and how single and multi-parameter persistent homology provide insights to biological systems.
URL:https://www.ibs.re.kr/bimag/event/tbd-heather-harrington/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/08/Heather-Harrington.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250929T160000
DTEND;TZID=Asia/Seoul:20250929T180000
DTSTAMP:20260422T114402
CREATED:20250920T051453Z
LAST-MODIFIED:20250920T051820Z
UID:11596-1759161600-1759168800@www.ibs.re.kr
SUMMARY:Excess Mortality\, Two Lenses : Healthcare Access and Cross-National Time Trends - Daeil Jang
DESCRIPTION:Abstract\nBackground : Excess mortality captures both the direct and indirect impacts of the pandemic. We examine (1) within-country heterogeneity by healthcare access over distinct viral waves in Korea\, and (2) cross-country associations between excess mortality and preparedness (Global Health Security\, GHS)\, stratified by IMF development stage. \nMethods : Study 1 assembled a region-level panel linking excess deaths (observed–expected) with healthcare access indicators (capacity\, travel time\, etc.) and estimated fixed-effects/event-study models across epidemic phases. Study 2 analyzed 60 countries\, relating standardized excess mortality rates to GHS scores\, with correlations/regressions reported within IMF development groups. \nResults : In Korea\, healthcare access was significantly associated with higher excess mortality only during the Omicron surge\, with no consistent differences in earlier phases—suggesting that access constraints translate into excess deaths primarily under acute demand spikes. Globally\, excess mortality showed an overall negative association with GHS scores\, but the magnitude and significance differed by IMF development stage\, indicating effect modification\nby structural context. \nConclusions : During rapid surges (e.g.\, Omicron)\, access bottlenecks—beds\, staffing\, transport—are closely linked to excess deaths. Internationally\, preparedness capacity matters\, yet its protective association varies with development level. Policy priorities include\nsurge capacity\, timely access pathways\, and context-tailored preparedness investments; future work should strengthen causal inference with age standardization\, reporting-delay adjustments\, and cause-specific linkages.
URL:https://www.ibs.re.kr/bimag/event/excess-mortality-two-lenses-healthcare-access-and-cross-national-time-trends/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250926T100000
DTEND;TZID=Asia/Seoul:20250926T113000
DTSTAMP:20260422T114402
CREATED:20250915T083322Z
LAST-MODIFIED:20250924T001304Z
UID:11589-1758880800-1758886200@www.ibs.re.kr
SUMMARY:Tackling inter-subject variability in smartwatch data using factorization models - Myna Lim
DESCRIPTION:In this talk\, we discuss the paper “Tackling inter-subject variability in smartwatch data using factorization models” by Arman Naseri et. al\, Scientific Reports\, 2025. \nAbstract \nSmartwatches enable longitudinal and continuous data acquisition. This has the potential to remotely monitor (changes) of the health of users. However\, differences among subjects (inter-subject variability) limit a model to generalize to unseen subjects. This study focused on binary classification tasks using heart rate and step counter from smartwatches\, including night/day and inactive/active classification\, as well as sleep and SpO2-related (oxygen saturation) tasks. To address inter-subject variability\, we explored different transforming and normalization regimes for time series including per-subject and population-based strategies. We propose a modified factorized autoencoder\, which separates the data into two latent spaces capturing class-specific and subject-specific information. Our proposed generalized factorized autoencoder and triplet factorized autoencoder improved classification accuracy over the baseline from 74.8 (± 10.5) to 83.1 (± 5.1) and 83.4 (± 5.3)\, respectively\, for night/day classification\, gains for inactive/active classification were modest\, improving from 84.3 (± 9.4) to 86.9 (± 4.4) and 86.6 (± 4.3)\, respectively. Our study highlights challenges of handling inter-subject variability in smartwatch data and how factorization models can be used to enable more robust and personalized health monitoring solutions for diverse populations.
URL:https://www.ibs.re.kr/bimag/event/tackling-inter-subject-variability-in-smartwatch-data-using-factorization-models-myna-lim/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250924T160000
DTEND;TZID=Asia/Seoul:20250924T170000
DTSTAMP:20260422T114402
CREATED:20250826T002622Z
LAST-MODIFIED:20250924T005005Z
UID:11453-1758729600-1758733200@www.ibs.re.kr
SUMMARY:Sleep as part of the 24-hour day: Methods and Applications in Oncology - Joshua Wiley
DESCRIPTION:Abstract \nSleep is commonly analysed as an independent factor. However\, because of the 24-hour constraints on a day\, changes in sleep will co-occur with changes in remaining time use. This talk introduces compositional data analysis (CoDA) for sleep research. CoDA is illustrated using 24-hour sleep and activity data from accelerometry\, first cross-sectionally showing associations between sleep and activity with daily emotions. Next\, CoDA is extended to multilevel models\, which commonly occur in sleep research as sleep across multiple days. A Bayesian implementation in R using the new multilevelcoda package is presented and results of a simulation study discussed. Multilevel CoDA is used to analyse how nightly sleep architecture\, collected via at home EEG\, predicts next day affect. CoDA solves a common constraint in sleep research with sleep stages that time in all stages sums to total sleep.
URL:https://www.ibs.re.kr/bimag/event/tbd-joshua-wiley/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/08/HMBrLrlLQZeLrC0q8bRL-e1756168492672.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250919T160000
DTEND;TZID=Asia/Seoul:20250919T180000
DTSTAMP:20260422T114402
CREATED:20250825T081133Z
LAST-MODIFIED:20250901T020244Z
UID:11435-1758297600-1758304800@www.ibs.re.kr
SUMMARY:SCassist: An AI Based Workflow Assistant for Single-Cell Analysis - Aqsa Awan
DESCRIPTION:In this talk\, we discuss the paper “SCassist: An AI Based Workflow Assistant for Single-Cell Analysis ” by Vijayaraj Nagarajan et al.\, bioarxiv\, 2025.  \nAbstract \nSingle-cell RNA sequencing (scRNA-seq) data analysis often involves complex iterative workflow\, requiring significant expertise and time. To navigate this complexity\, we have developed SCassist\, an R package that leverages the power of the large language models (LLM’s) to guide and enhance scRNA-seq analysis. SCassist integrates LLM’s into key workflow steps\, to analyze user data and provide relevant recommendations for filtering\, normalization and clustering parameters. It also provides LLM guided insightful interpretations of variable features and principal components\, along with cell type annotations and enrichment analysis. SCassist provides intelligent assistance using popular LLM’s like Google’s Gemini\, OpenAI’s GPT and Meta’s Llama3\, making scRNA-seq analysis accessible to researchers at all levels.
URL:https://www.ibs.re.kr/bimag/event/scassist-an-ai-based-workflow-assistant-for-single-cell-analysis-aqsa-awan/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250912T140000
DTEND;TZID=Asia/Seoul:20250912T160000
DTSTAMP:20260422T114402
CREATED:20250825T081619Z
LAST-MODIFIED:20250910T002342Z
UID:11438-1757685600-1757692800@www.ibs.re.kr
SUMMARY:Decomposing causality into its synergistic\, unique\, and redundant components - Olive Cawiding
DESCRIPTION:In this talk\, we discuss the paper “Decomposing causality into its synergistic\, unique\, and redundant components” by Álvaro Martínez-Sánchez et al.\, Nature Communications\, 2024. \nAbstract \nCausality lies at the heart of scientific inquiry\, serving as the fundamental basis for understanding interactions among variables in physical systems. Despite its central role\, current methods for causal inference face significant challenges due to nonlinear dependencies\, stochastic interactions\, self-causation\, collider effects\, and influences from exogenous factors\, among others. While existing methods can effectively address some of these challenges\, no single approach has successfully integrated all these aspects. Here\, we address these challenges with SURD: Synergistic-Unique-Redundant Decomposition of causality. SURD quantifies causality as the increments of redundant\, unique\, and synergistic information gained about future events from past observations. The formulation is non-intrusive and applicable to both computational and experimental investigations\, even when samples are scarce. We benchmark SURD in scenarios that pose significant challenges for causal inference and demonstrate that it offers a more reliable quantification of causality compared to previous methods.
URL:https://www.ibs.re.kr/bimag/event/data-driven-model-discovery-and-model-selection-for-noisy-biological-systems-olive-cawiding/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250905T140000
DTEND;TZID=Asia/Seoul:20250905T160000
DTSTAMP:20260422T114402
CREATED:20250825T080853Z
LAST-MODIFIED:20250901T020216Z
UID:11433-1757080800-1757088000@www.ibs.re.kr
SUMMARY:Physics-constrained neural ordinary differential equation models to discover and predict microbial community dynamics - Kang Min Lee
DESCRIPTION:In this talk\, we discuss the paper “Physics-constrained neural ordinary differential equation models to discover and predict microbial community dynamics” by J. Thompson et al.\, bioarxiv\, 2025. \nAbstract \nMicrobial communities play essential roles in shaping ecosystem functions and predictive modeling frameworks are crucial for understanding\, controlling\, and harnessing their properties. Competition and cross-feeding of metabolites drives microbiome dynamics and functions. Existing mechanistic models that capture metabolite-mediated interactions in microbial communities have limited flexibility due to rigid assumptions. While machine learning models provide flexibility\, they require large datasets\, are challenging to interpret\, and can over-fit to experimental noise. To overcome these limitations\, we develop a physics-constrained machine learning model\, which we call the Neural Species Mediator (NSM)\, that combines a mechanistic model of metabolite dynamics with a machine learning component. The NSM is more accurate than mechanistic or machine learning components on experimental datasets and provides insights into direct biological interactions. In summary\, embedding a neural network into a mechanistic model of microbial community dynamics improves prediction performance and interpretability compared to its constituent mechanistic or machine learning components.
URL:https://www.ibs.re.kr/bimag/event/physics-constrained-neural-ordinary-differential-equation-models-to-discover-and-predict-microbial-community-dynamics-kang-min-lee/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250903T160000
DTEND;TZID=Asia/Seoul:20250903T170000
DTSTAMP:20260422T114402
CREATED:20250826T002752Z
LAST-MODIFIED:20250826T003557Z
UID:11450-1756915200-1756918800@www.ibs.re.kr
SUMMARY:Weak form SciML in the Life Sciences: The Weak Form is Stronger than you Think - David Bortz
DESCRIPTION:Abstract \nThe creation and inference of mathematical models is central to modern scientific discovery in the life sciences. As more realism is demanded of models\, however\, the conventional framework of biology-guided model proposal\, discretization\, parameter estimation\, and model refinement becomes unwieldy\, expensive\, and computationally daunting. Recent advances in Weak form-based Scientific Machine Learning (WSciML) allow for the creation and inference of interpretable models directly from data via advanced numerical functional analysis\, computational statistics\, and numerical linear algebra techniques. This class of methods completely bypasses the need for forward-solve numerical discretizations and yields both parsimonious mathematical models and efficient parameter estimates. These methods are orders of magnitude faster and more accurate than traditional approaches and far more robust to the high noise levels common to data in the biological sciences. The combination of these features in a single framework provides a compelling alternative to both traditional modeling approaches as well as modern black-box neural networks. In this talk\, I will present our weak form approach\, describing our equation learning (WSINDy) and parameter estimation (WENDy) algorithms. I will demonstrate these performance properties via applications to several canonical problems in structured population modeling\, cell migration\, and mathematical epidemiology.
URL:https://www.ibs.re.kr/bimag/event/weak-form-sciml-in-the-life-sciences-the-weak-form-is-stronger-than-you-think-david-bortz/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/avif:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/08/David-Bortz.jpg-e1756168544295.avif
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250829T140000
DTEND;TZID=Asia/Seoul:20250829T160000
DTSTAMP:20260422T114402
CREATED:20250727T024418Z
LAST-MODIFIED:20250727T024418Z
UID:11348-1756476000-1756483200@www.ibs.re.kr
SUMMARY:Binning as a Pretext Task: Improving Self-Supervised Learning in Tabular Domains - Jinwoo Hyun
DESCRIPTION:In this talk\, we discuss the paper “Binning as a Pretext Task: Improving Self-Supervised Learning in Tabular Domains” by K. Lee. \nAbstract \nThe ability of deep networks to learn superior representations hinges on leveraging the proper inductive biases\, considering the inherent properties of datasets. In tabular domains\, it is critical to effectively handle heterogeneous features (both categorical and numerical) in a unified manner and to grasp irregular functions like piecewise constant functions. To address the challenges in the self-supervised learning framework\, we propose a novel pretext task based on the classical binning method. The idea is straightforward: reconstructing the bin indices (either orders or classes) rather than the original values. This pretext task provides the encoder with an inductive bias to capture the irregular dependencies\, mapping from continuous inputs to discretized bins\, and mitigates the feature heterogeneity by setting all features to have category-type targets. Our empirical investigations ascertain several advantages of binning: compatibility with encoder architecture and additional modifications\, standardizing all features into equal sets\, grouping similar values within a feature\, and providing ordering information. Comprehensive evaluations across diverse tabular datasets corroborate that our method consistently improves tabular representation learning performance for a wide range of downstream tasks. The codes are available in the supplementary material.
URL:https://www.ibs.re.kr/bimag/event/binning-as-a-pretext-task-improving-self-supervised-learning-in-tabular-domains-jinwoo-hyun/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250822T153000
DTEND;TZID=Asia/Seoul:20250822T173000
DTSTAMP:20260422T114402
CREATED:20250803T065046Z
LAST-MODIFIED:20250819T002937Z
UID:11366-1755876600-1755883800@www.ibs.re.kr
SUMMARY:Statistical method scDEED for detecting dubious 2D single-cell embeddings and optimizing t-SNE and UMAP hyperparameters - Kevin Spinicci
DESCRIPTION:In this talk\, we discuss the paper “Statistical method scDEED for detecting dubious 2D single-cell embeddings and optimizing t-SNE and UMAP hyperparameters” by L. Xia et.al. Nature Communications\, 2024. \nAbstract \nTwo-dimensional (2D) embedding methods are crucial for single-cell data visualization. Popular methods such as t-distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation and projection (UMAP) are commonly used for visualizing cell clusters; however\, it is well known that t-SNE and UMAP’s 2D embeddings might not reliably inform the similarities among cell clusters. Motivated by this challenge\, we present a statistical method\, scDEED\, for detecting dubious cell embeddings output by a 2D-embedding method. By calculating a reliability score for every cell embedding based on the similarity between the cell’s 2D-embedding neighbors and pre-embedding neighbors\, scDEED identifies the cell embeddings with low reliability scores as dubious and those with high reliability scores as trustworthy. Moreover\, by minimizing the number of dubious cell embeddings\, scDEED provides intuitive guidance for optimizing the hyperparameters of an embedding method. We show the effectiveness of scDEED on multiple datasets for detecting dubious cell embeddings and optimizing the hyperparameters of t-SNE and UMAP.
URL:https://www.ibs.re.kr/bimag/event/context-aware-deconvolution-of-cell-cell-communication-with-tensor-cell2cell-kevin-spinicci/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250808T140000
DTEND;TZID=Asia/Seoul:20250808T160000
DTSTAMP:20260422T114402
CREATED:20250727T024732Z
LAST-MODIFIED:20250727T024732Z
UID:11351-1754661600-1754668800@www.ibs.re.kr
SUMMARY:Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan - Yun Min Song
DESCRIPTION:In this talk\, we discuss the paper “Circadian rhythm analysis using wearable-based accelerometry as a digital biomarker of aging and healthspan” by J. Shim et.al.\, npj digital medicine\, 2024. \nAbstract \nRecognizing the pivotal role of circadian rhythm in the human aging process and its scalability through wearables\, we introduce CosinorAge\, a digital biomarker of aging developed from wearable-derived circadian rhythmicity from 80\,000 midlife and older adults in the UK and US. A one-year increase in\nCosinorAge corresponded to 8–12% higher all-cause and cause-specific mortality risks and 3–14% increased prospective incidences of age-related diseases. CosinorAge also captured a non-linear decline in resilience and physical functioning\, evidenced by an 8–33% reduction in self-rated health\nand a 3–23% decline in health-related quality of life score\, adjusting for covariates and multiple testing. The associations were robust in sensitivity analyses and external validation using an independent cohort from a disparate geographical region using a different wearable device. Moreover\, we\nillustrated a heterogeneous impact of circadian parameters associated with biological aging\, with young (<45 years) and fast agers experiencing a substantially delayed acrophase with a 25-minute difference in peak timing compared to slow agers\, diminishing to a 7-minute difference in older adults\n(>65 years). We demonstrated a significant enhancement in the predictive performance when integrating circadian rhythmicity in the estimation of biological aging over physical activity. Our findings underscore CosinorAge’s potential as a scalable\, economic\, and digital solution for promoting healthy longevity\, elucidating the critical and multifaceted circadian rhythmicity in aging processes. Consequently\, our research contributes to advancing preventive measures in digital medicine.
URL:https://www.ibs.re.kr/bimag/event/circadian-rhythm-analysis-using-wearable-based-accelerometry-as-a-digital-biomarker-of-aging-and-healthspan-yun-min-song/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250806T150000
DTEND;TZID=Asia/Seoul:20250806T170000
DTSTAMP:20260422T114402
CREATED:20250804T010321Z
LAST-MODIFIED:20250824T041110Z
UID:11368-1754492400-1754499600@www.ibs.re.kr
SUMMARY:Jooyoung Hahn - Topological Data Analysis with two applications: Tumor Microenvironment and  2D Chromatography with High-Resolution Mass Spectrometry
DESCRIPTION:Abstract  \nTopological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional\, complex datasets. In this talk\, we present two applications of TDA in analyzing patterns\, one in the tumor microenvironment (TME) and the other in high-resolution chemical profiling. In the first case\, we develop a TDA-based framework to quantify malignant-immune cell interactions in Diffuse Large B Cell Lymphoma using multiplex immunofluorescence imaging. By introducing Topological Malignant Clusters (TopMC) and leveraging persistence diagrams\, we capture both global infiltration patterns and local density-based features. This robust approach enables consistent prognostic assessment regardless of tumor region heterogeneity and reveals correlations with patient survival. In the second application\, we utilize the Ball Mapper algorithm to simplify and visualize high-dimensional data obtained from 2D Chromatography with high-resolution mass spectrometry. This enables interpretable chemical profiling of complex mixtures and supports tasks such as sample authentication and environmental analysis. Together\, these studies demonstrate the versatility and interpretability of TDA for extracting biologically and chemically meaningful information. \nSeminar Video Link: https://www.youtube.com/watch?v=mz9pY6nk3n4&t=12s
URL:https://www.ibs.re.kr/bimag/event/jooyoung-hahn-topological-data-analysis-with-two-applications-tumor-microenvironment-and-2d-chromatography-with-high-resolution-mass-spectrometry/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250801T140000
DTEND;TZID=Asia/Seoul:20250801T160000
DTSTAMP:20260422T114402
CREATED:20250727T024030Z
LAST-MODIFIED:20250727T024047Z
UID:11346-1754056800-1754064000@www.ibs.re.kr
SUMMARY:Quantifying the energy landscape of high-dimensional oscillatory systems by diffusion decomposition - Eui Min Jeong
DESCRIPTION:In this talk\, we discuss the paper “Quantifying the energy landscape of high-dimensional oscillatory systems by diffusion decomposition” by S. Bian et.al.\, Cell Reports Physical Science\, 2025. \nAbstract \nHigh-dimensional networks producing oscillatory dynamics are ubiquitous in biological systems. Unraveling the mechanism of oscillatory dynamics in biological networks with stochastic perturbations becomes of paramount significance. Although the classical energy landscape theory provides a tool to study this problem in multistable systems and explain cellular functions\, it remains challenging to accurately quantify the landscape for high-dimensional oscillatory systems. Here\, we propose an approach called the diffusion decomposition of Gaussian approximation (DDGA). We demonstrate the efficacy of the DDGA in quantifying the energy landscape of oscillatory systems and corresponding stochastic dynamics in comparison with existing approaches. By further applying the DDGA to high-dimensional biological networks\, we are able to uncover more intricate biological mechanisms efficiently\, which deepens our understanding of cellular functions.
URL:https://www.ibs.re.kr/bimag/event/quantifying-the-energy-landscape-of-high-dimensional-oscillatory-systems-by-diffusion-decomposition-eui-min-jeong/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250725T140000
DTEND;TZID=Asia/Seoul:20250725T160000
DTSTAMP:20260422T114402
CREATED:20250628T123019Z
LAST-MODIFIED:20250721T002532Z
UID:11218-1753452000-1753459200@www.ibs.re.kr
SUMMARY:Effective Markovian dynamics method of solving non-Markovian dynamics of stochastic gene expression - Dongju Lim
DESCRIPTION:In this talk\, we discuss the paper “Effective Markovian dynamics method of solving non-Markovian dynamics of stochastic gene expression” by Youming Li and Chen Jia\, Physical Review Letters\, to appear. \nAbstract \nExperiments have shown that over 10% of proteins are degraded non-exponentially. Gene expression models for non-exponentially degraded proteins are notoriously difficult to solve since the underlying stochastic dynamics is non-Markovian. Here we develop an effective Markovian dynamics (EMD) method which converts a large class of non-Markovian models into effective Markovian ones so that they have the same mRNA and protein distributions at any fixed time. Using the EMD approach\, we analytically solve some classical gene expression models with non-exponential or delayed protein decay\, whose exact distributions are previously unknown and fail to be obtained using conventional queueing theory. Our theory successfully explains why non-exponentially degraded proteins on average have smaller mRNA-protein correlation than exponentially degraded proteins\, and it predicts that bimodality is significantly enhanced in the presence of delayed protein degradation.
URL:https://www.ibs.re.kr/bimag/event/action-functional-as-an-early-warning-indicator-in-the-space-of-probability-measures-via-schrodinger-bridge-dongju-lim/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250721T110000
DTEND;TZID=Asia/Seoul:20250721T120000
DTSTAMP:20260422T114402
CREATED:20250617T084231Z
LAST-MODIFIED:20250617T084231Z
UID:11189-1753095600-1753099200@www.ibs.re.kr
SUMMARY:Jae-Kwang Kim - Weight calibration for causal inference and transfer learning
DESCRIPTION:Abstract: Weight calibration is a popular technique in handling covariate-shift problem in causal inference. It can be viewed as a dual optimization problem for incorporating the implicit regression model. We introduce the generalized entropy calibration as a general tool for weight calibration. Several interesting applications will be introduced in the context of causal inference. Furthermore\, weight calibration can be used to transfer learning\, which combines information from two different samples\, one for source data and the other for target data.
URL:https://www.ibs.re.kr/bimag/event/jae-kwang-kim-weight-calibration-for-causal-inference-and-transfer-learning/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250718T140000
DTEND;TZID=Asia/Seoul:20250718T160000
DTSTAMP:20260422T114402
CREATED:20250701T022224Z
LAST-MODIFIED:20250701T022224Z
UID:11231-1752847200-1752854400@www.ibs.re.kr
SUMMARY:scGPT: toward building a foundation model for single-cell multi-omics using generative AI - Hyun Kim
DESCRIPTION:In this talk\, we discuss the paper “scGPT: toward building a foundation model for single-cell multi-omics using generative AI” by Haotian Cui\, et.al. Nature Methods\, 2024. \nAbstract \nGenerative pretrained models have achieved remarkable success in various domains such as language and computer vision. Specifically\, the combination of large-scale diverse datasets and pretrained transformers has emerged as a promising approach for developing foundation models. Drawing parallels between language and cellular biology (in which texts comprise words; similarly\, cells are defined by genes)\, our study probes the applicability of foundation models to advance cellular biology and genetic research. Using burgeoning single-cell sequencing data\, we have constructed a foundation model for single-cell biology\, scGPT\, based on a generative pretrained transformer across a repository of over 33 million cells. Our findings illustrate that scGPT effectively distills critical biological insights concerning genes and cells. Through further adaptation of transfer learning\, scGPT can be optimized to achieve superior performance across diverse downstream applications. This includes tasks such as cell type annotation\, multi-batch integration\, multi-omic integration\, perturbation response prediction and gene network inference.
URL:https://www.ibs.re.kr/bimag/event/scgpt-toward-building-a-foundation-model-for-single-cell-multi-omics-using-generative-ai-hyun-kim/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250711T140000
DTEND;TZID=Asia/Seoul:20250711T160000
DTSTAMP:20260422T114402
CREATED:20250628T122808Z
LAST-MODIFIED:20250628T122808Z
UID:11216-1752242400-1752249600@www.ibs.re.kr
SUMMARY:Optimal transport for generating transition states in chemical reactions - Gyuyoung Hwang
DESCRIPTION:In this talk\, we discuss the paper “Optimal transport for generating transition states in chemical reactions” by C. Duan et.al.\, Nat. Machine. Intelligence\, 2025. \nAbstract \nTransition states (TSs) are transient structures that are key to understanding reaction mechanisms and designing catalysts but challenging to capture in experiments. Many optimization algorithms have been developed to search for TSs computationally. Yet\, the cost of these algorithms driven by quantum chemistry methods (usually density functional theory) is still high\, posing challenges for their applications in building large reaction networks for reaction exploration. Here we developed React-OT\, an optimal transport approach for generating unique TS structures from reactants and products. React-OT generates highly accurate TS structures with a median structural root mean square deviation of 0.053 Å and median barrier height error of 1.06 kcal mol−1 requiring only 0.4 s per reaction. The root mean square deviation and barrier height error are further improved by roughly 25% through pretraining React-OT on a large reaction dataset obtained with a lower level of theory\, GFN2-xTB. We envision that the remarkable accuracy and rapid inference of React-OT will be highly useful when integrated with the current high-throughput TS search workflow. This integration will facilitate the exploration of chemical reactions with unknown mechanisms.
URL:https://www.ibs.re.kr/bimag/event/optimal-transport-for-generating-transition-states-in-chemical-reactions-gyuyoung-hwang/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250704T140000
DTEND;TZID=Asia/Seoul:20250704T160000
DTSTAMP:20260422T114402
CREATED:20250526T004910Z
LAST-MODIFIED:20250609T001902Z
UID:11146-1751637600-1751644800@www.ibs.re.kr
SUMMARY:Machine learning methods trained on simple models can predict critical transitions in complex natural systems - Shingo Gibo
DESCRIPTION:In this talk\, we discuss the paper “Machine learning methods trained on simple models can predict critical transitions in complex natural systems” by  Smita Deb\, Sahil Sidheekh\, Christopher F. Clements\, Narayanan C. Krishnan\, and Partha S. Dutta\, in Royal Society Open Science\, (2022). \nAbstract:  \nForecasting sudden changes in complex systems is a critical but challenging task\, with previously developed methods varying widely in their reliability. Here we develop a novel detection method\, using simple theoretical models to train a deep neural network to detect critical transitions—the Early Warning Signal Network (EWSNet). We then demonstrate that this network\, trained on simulated data\, can reliably predict observed real-world transitions in systems ranging from rapid climatic change to the collapse of ecological populations. Importantly\, our model appears to capture latent properties in time series missed by previous warning signals approaches\, allowing us to not only detect if a transition is approaching\, but critically whether the collapse will be catastrophic or non-catastrophic. These novel properties mean EWSNet has the potential to serve as an indicator of transitions across a broad spectrum of complex systems\, without requiring information on the structure of the system being monitored. Our work highlights the practicality of deep learning for addressing further questions pertaining to ecosystem collapse and has much broader management implications.
URL:https://www.ibs.re.kr/bimag/event/machine-learning-methods-trained-on-simple-models-can-predict-critical-transitions-in-complex-natural-systems-shingo-gibo/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250703T160000
DTEND;TZID=Asia/Seoul:20250703T170000
DTSTAMP:20260422T114402
CREATED:20250628T074404Z
LAST-MODIFIED:20250630T055202Z
UID:11207-1751558400-1751562000@www.ibs.re.kr
SUMMARY:Jihun Han - Bridging PDEs and machine learning
DESCRIPTION:Abstract: This talk consists of two main parts. In the first part\, I will discuss a numerical method for solving PDEs based on a stochastic representation of the solution. This approach captures the underlying particle dynamics associated with the physical processes described by the PDE. By aggregating information from the particles’ collective exploration\, the method iteratively reinforces the approximation toward the solution. I will cover its analysis regarding the trainability and highlight its effectiveness across a broad class of problems\, including elliptic equations with interfaces\, multiscale structures\, and perforated domains\, as well as hyperbolic-type problems such as the Eikonal and Burgers equations.\nIn the second part\, I will present a method for learning in-between imagery dynamics. This approach integrates PDE models within latent spaces to enhance both learning capability and interpretability. Notably\, this method demonstrates robustness in capturing intricate dynamics\, such as rotation and outflow\, which pose significant challenges for current state-of-the-art optimal transport methods.
URL:https://www.ibs.re.kr/bimag/event/ji-hoon-han-bridging-pdes-and-machine-learning/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250627T160000
DTEND;TZID=Asia/Seoul:20250627T170000
DTSTAMP:20260422T114402
CREATED:20250615T110211Z
LAST-MODIFIED:20250615T110211Z
UID:11180-1751040000-1751043600@www.ibs.re.kr
SUMMARY:U Jin Choi - Simulation-Free Schrodinger Bridges Via Score and Flow Matching (by Tong et al\, AISTATS 2024).
DESCRIPTION:Abstract: 임의로 정한 Initial Distribution Q1 와 Terminal Distribution Q2가 주어 졌을 때 시점과 종점 사이의 contiinious time상에  정의 되는 의미 있는 최적의 Probability Path Measure P 를 찾는 Schrodinger Bridges Problem 은 자연과학\,공학\, 의료 및 생명공학\,경제학 및 금융공학 등의 여러 분야에 나타나는 모델들을 푸는 Unified AI Model 사용 되고 있습니다. Schrodinger Bridges Problem은  유일한 해가 존재 하는 정리는( Follmer\,1988)  증명 되었으므로 데이터를 이용하여  Neural Network Models에 대한 효율적으로 학습방법\,  빠른 알고리즘 연구에 집중 되고 있습니다. Tong et al 연구팀은 2023년 부터 ODE에 기반한 획기적인 생성모델인  Flow Matching for Generative Modeling 기법을  SDE 기반 Diffusion Generative Models에 접목하여 Schrodinger Bridges Problem의 해법을 제시하였습니다.
URL:https://www.ibs.re.kr/bimag/event/u-jin-choi-simulation-free-schrodinger-bridges-via-score-and-flow-matching-by-tong-et-al-aistats-2024/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250627T140000
DTEND;TZID=Asia/Seoul:20250627T160000
DTSTAMP:20260422T114402
CREATED:20250426T143642Z
LAST-MODIFIED:20250609T001825Z
UID:11067-1751032800-1751040000@www.ibs.re.kr
SUMMARY:Data splitting to avoid information leakage with DataSAIL - Myna Lim
DESCRIPTION:In this talk\, we discuss the paper\, “Data splitting to avoid information leakage with DataSAIL” by Roman Joeres\, et al.\, Nature Communications\, 2025. \nAbstract \nInformation leakage is an increasingly important topic in machine learning research for biomedical applications. When information leakage happens during a model’s training\, it risks memorizing the training data instead of learning generalizable properties. This can lead to inflated performance metrics that do not reflect the actual performance at inference time. We present DataSAIL\, a versatile Python package to facilitate leakage-reduced data splitting to enable realistic evaluation of machine learning models for biological data that are intended to be applied in out-of-distribution scenarios. DataSAIL is based on formulating the problem to find leakage-reduced data splits as a combinatorial optimization problem. We prove that this problem is NP-hard and provide a scalable heuristic based on clustering and integer linear programming. Finally\, we empirically demonstrate DataSAIL’s impact on evaluating biomedical machine learning models.
URL:https://www.ibs.re.kr/bimag/event/data-splitting-to-avoid-information-leakage-with-datasail-myna-lim/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250620T110000
DTEND;TZID=Asia/Seoul:20250620T123000
DTSTAMP:20260422T114402
CREATED:20250426T143500Z
LAST-MODIFIED:20250617T001232Z
UID:11064-1750417200-1750422600@www.ibs.re.kr
SUMMARY:Large language models for scientific discovery in molecular property prediction - Aqsa Awan
DESCRIPTION:In this talk\, we discuss the paper “Large language models for scientific discovery in molecular property prediction” by Yizhen Zheng et.al.\, nature machine intelligence\, 2025. \nAbstract \nLarge language models (LLMs) are a form of artificial intelligence system encapsulating vast knowledge in the form of natural language. These systems are adept at numerous complex tasks including creative writing\, storytelling\, translation\, question-answering\, summarization and computer code generation. Although LLMs have seen initial applications in natural sciences\, their potential for driving scientific discovery remains largely unexplored. In this work\, we introduce LLM4SD\, a framework designed to harness LLMs for driving scientific discovery in molecular property prediction by synthesizing knowledge from literature and inferring knowledge from scientific data. LLMs synthesize knowledge by extracting established information from scientific literature\, such as molecular weight being key to predicting solubility. For inference\, LLMs identify patterns in molecular data\, particularly in Simplified Molecular Input Line Entry System-encoded structures\, such as halogen-containing molecules being more likely to cross the blood–brain barrier. This information is presented as interpretable knowledge\, enabling the transformation of molecules into feature vectors. By using these features with interpretable models such as random forest\, LLM4SD can outperform the current state of the art across a range of benchmark tasks for predicting molecular properties. We foresee it providing interpretable and potentially new insights\, aiding scientific discovery in molecular property prediction.
URL:https://www.ibs.re.kr/bimag/event/large-language-models-for-scientific-discovery-in-molecular-property-prediction-aqsa-awan/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250613T093000
DTEND;TZID=Asia/Seoul:20250613T110000
DTSTAMP:20260422T114402
CREATED:20250609T002038Z
LAST-MODIFIED:20250609T033628Z
UID:11164-1749807000-1749812400@www.ibs.re.kr
SUMMARY:Deep learning for universal linear embeddings of nonlinear dynamics - Hyukpyo Hong
DESCRIPTION:In this talk\, we discuss the paper “Deep learning for universal linear embeddings of nonlinear dynamics” by B. Lusch\, J. N. Kutz\, and S. Brunton\, Nat. Comm. 2018. \nAbstract  \nIdentifying coordinate transformations that make strongly nonlinear dynamics approximately linear has the potential to enable nonlinear prediction\, estimation\, and control using linear theory. The Koopman operator is a leading data-driven embedding\, and its eigenfunctions provide intrinsic coordinates that globally linearize the dynamics. However\, identifying and representing these eigenfunctions has proven challenging. This work leverages deep learning to discover representations of Koopman eigenfunctions from data. Our network is parsimonious and interpretable by construction\, embedding the dynamics on a low-dimensional manifold. We identify nonlinear coordinates on which the dynamics are globally linear using a modified auto-encoder. We also generalize Koopman representations to include a ubiquitous class of systems with continuous spectra. Our framework parametrizes the continuous frequency using an auxiliary network\, enabling a compact and efficient embedding\, while connecting our models to decades of asymptotics. Thus\, we benefit from the power of deep learning\, while retaining the physical interpretability of Koopman embeddings.
URL:https://www.ibs.re.kr/bimag/event/hyukpyo-hong/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250530T140000
DTEND;TZID=Asia/Seoul:20250530T160000
DTSTAMP:20260422T114402
CREATED:20250426T143239Z
LAST-MODIFIED:20250528T035910Z
UID:11061-1748613600-1748620800@www.ibs.re.kr
SUMMARY:Direct Estimation of Parameters in ODE Models Using WENDy - Kangmin Lee
DESCRIPTION:In this talk\, we discuss the paper “Direct Estimation of Parameters in ODE Models Using WENDy: Weak-Form Estimation of Nonlinear Dynamics” by David M. Bortz\, Daniel A. Messenger\, and Vanja Dukic\, Bulletin of Mathematical Biology\, 2023. \nAbstract \nWe introduce the Weak-form Estimation of Nonlinear Dynamics (WENDy) method for estimating model parameters for non-linear systems of ODEs. Without relying on any numerical differential equation solvers\, WENDy computes accurate estimates and is robust to large (biologically relevant) levels of measurement noise. For low dimensional systems with modest amounts of data\, WENDy is competitive with conventional forward solver-based nonlinear least squares methods in terms of speed and accuracy. For both higher dimensional systems and stiff systems\, WENDy is typically both faster (often by orders of magnitude) and more accurate than forward solver-based approaches. The core mathematical idea involves an efficient conversion of the strong form representation of a model to its weak form\, and then solving a regression problem to perform parameter inference. The core statistical idea rests on the Errors-In-Variables framework\, which necessitates the use of the iteratively reweighted least squares algorithm. Further improvements are obtained by using orthonormal test functions\, created from a set of C∞ bump functions of varying support sizes.We demonstrate the high robustness and computational efficiency by applying WENDy to estimate parameters in some common models from population biology\, neuroscience\, and biochemistry\, including logistic growth\, Lotka-Volterra\, FitzHugh-Nagumo\, Hindmarsh-Rose\, and a Protein Transduction Benchmark model. Software and code for reproducing the examples is available at https://github.com/MathBioCU/WENDy.
URL:https://www.ibs.re.kr/bimag/event/quantifying-and-correcting-bias-in-transcriptional-parameter-inference-from-single-cell-data-kangmin-lee/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250530T110000
DTEND;TZID=Asia/Seoul:20250530T120000
DTSTAMP:20260422T114402
CREATED:20250217T081212Z
LAST-MODIFIED:20250217T082031Z
UID:10780-1748602800-1748606400@www.ibs.re.kr
SUMMARY:Koopman operator approach to complex rhythmic systems - Hiroya Nakao
DESCRIPTION:Abstract \nSpontaneous rhythmic oscillations are widely observed in real-world systems. Synchronized rhythmic oscillations often provide important functions for biological or engineered systems. One of the useful theoretical methods for analyzing rhythmic oscillations is the phase reduction theory for weakly perturbed limit-cycle oscillators\, which systematically gives a low-dimensional description of the oscillatory dynamics using only the asymptotic phase of the oscillator. Recent advances in Koopman operator theory provide a new viewpoint on phase reduction\, yielding an operator-theoretic definition of the classical notion of the asymptotic phase and\, moreover\, of the amplitudes\, which characterize distances from the limit cycle. This led to the generalization of classical phase reduction to phase-amplitude reduction\, which can characterize amplitude deviations of the oscillator from the unperturbed limit cycle in addition to the phase along the cycle in a systematic manner. In the talk\, these theories are briefly reviewed and then applied to several examples of synchronizing rhythmic systems\, including biological oscillators\, networked dynamical systems\, and rhythmic spatiotemporal patterns.
URL:https://www.ibs.re.kr/bimag/event/koopman-operator-approach-to-complex-rhythmic-systems-hiroya-nakao/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/02/nakao-hiroya.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250521T160000
DTEND;TZID=Asia/Seoul:20250521T170000
DTSTAMP:20260422T114402
CREATED:20250217T080703Z
LAST-MODIFIED:20250217T080703Z
UID:10775-1747843200-1747846800@www.ibs.re.kr
SUMMARY:Simplified descriptions of stochastic oscillators - Benjamin Lindner
DESCRIPTION:Abstract \nMany natural systems exhibit oscillations that show sizeable fluctuations in frequency and amplitude. This variability can arise from a wide variety of physical mechanisms. Phase descriptions that work for deterministic oscillators have a limited applicability for stochastic oscillators. In my talk I review attempts to generalize the phase concept to stochastic oscillations\, specifically\, the mean-return-time phase and the asymptotic phase.\nFor stochastic systems described by Fokker-Planck and Kolmogorov-backward equations\, I introduce a mapping of the system’s variables to a complex pointer (instead of a real-valued phase) that is based on the eigenfunction of the Kolmogorov equation. Under the new (complex-valued) description\, the statistics of the oscillator’s spontaneous activity\, of its response to external perturbations\, and of the coordinated activity of (weakly) coupled oscillators\, is brought into a universal and greatly simplified form. The theory is tested for three theoretical models of noisy oscillators arising from fundamentally different mechanisms: a damped harmonic oscillator with dynamical noise\, a fluctuation-perturbed limit-cycle system\, and an excitable system in which oscillations require noise to occur.
URL:https://www.ibs.re.kr/bimag/event/simplified-descriptions-of-stochastic-oscillators-benjamin-lindner/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/02/Benjamin-Lindner-e1739779616840.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250509T140000
DTEND;TZID=Asia/Seoul:20250509T160000
DTSTAMP:20260422T114402
CREATED:20250426T142850Z
LAST-MODIFIED:20250507T002814Z
UID:11058-1746799200-1746806400@www.ibs.re.kr
SUMMARY:Network inference from short\, noisy\, low time-resolution\, partial measurements: Application to C. elegans neuronal calcium dynamics - Olive Cawiding
DESCRIPTION:In this talk\, we discuss the paper “Network inference from short\, noisy\, low time-resolution\, partial measurements: Application to C. elegans neuronal calcium dynamics” by Amitava Banerjee\, Sarthak Chandra\, and Edward Ott\, PNAS\, 2023. \nAbstract \nNetwork link inference from measured time series data of the behavior of dynamically interacting network nodes is an important problem with wide-ranging applications\, e.g.\, estimating synaptic connectivity among neurons from measurements of their calcium fluorescence. Network inference methods typically begin by using the measured time series to assign to any given ordered pair of nodes a numerical score reflecting the likelihood of a directed link between those two nodes. In typical cases\, the measured time series data may be subject to limitations\, including limited duration\, low sampling rate\, observational noise\, and partial nodal state measurement. However\, it is unknown how the performance of link inference techniques on such datasets depends on these experimental limitations of data acquisition. Here\, we utilize both synthetic data generated from coupled chaotic systems as well as experimental data obtained from Caenorhabditis elegans neural activity to systematically assess the influence of data limitations on the character of scores reflecting the likelihood of a directed link between a given node pair. We do this for three network inference techniques: Granger causality\, transfer entropy\, and\, a machine learning-based method. Furthermore\, we assess the ability of appropriate surrogate data to determine statistical confidence levels associated with the results of link-inference techniques.
URL:https://www.ibs.re.kr/bimag/event/chaos-is-not-rare-in-natural-ecosystems-olive-cawiding/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250502T140000
DTEND;TZID=Asia/Seoul:20250502T160000
DTSTAMP:20260422T114402
CREATED:20250330T073307Z
LAST-MODIFIED:20250424T070416Z
UID:10929-1746194400-1746201600@www.ibs.re.kr
SUMMARY:Boolean modelling as a logic-based dynamic approach in systems medicine - Kevin Spinicci
DESCRIPTION:In this talk\, we discuss the paper “Boolean modelling as a logic-based dynamic approach in systems medicine” by Ahmed Abdelmonem Hemedan et al.\, Computational and Structural biotechnology journal (2022). \nAbstract  \nMolecular mechanisms of health and disease are often represented as systems biology diagrams\, and the coverage of such representation constantly increases. These static diagrams can be transformed into dynamic models\, allowing for in silico simulations and predictions. Boolean modelling is an approach based on an abstract representation of the system. It emphasises the qualitative modelling of biological systems in which each biomolecule can take two possible values: zero for absent or inactive\, one for present or active. Because of this approximation\, Boolean modelling is applicable to large diagrams\, allowing to capture their dynamic properties. We review Boolean models of disease mechanisms and compare a range of methods and tools used for analysis processes. We explain the methodology of Boolean analysis focusing on its application in disease modelling. Finally\, we discuss its practical application in analysing signal transduction and gene regulatory pathways in health and disease.
URL:https://www.ibs.re.kr/bimag/event/boolean-modelling-as-a-logic-based-dynamic-approach-in-systems-medicine-kevin-spinicci/
LOCATION:Daejeon
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250428T110000
DTEND;TZID=Asia/Seoul:20250428T120000
DTSTAMP:20260422T114402
CREATED:20250414T004912Z
LAST-MODIFIED:20250420T085852Z
UID:10975-1745838000-1745841600@www.ibs.re.kr
SUMMARY:FoodSeq: Using Genomics to Track and Study Diet - Lawrence David
DESCRIPTION:Abstract\nDietary assessment is crucial for understanding the relationship between diet and health. Yet traditional recall-based methods for tracking diet often face challenges like participant compliance and accurate recall. To address these issues\, our lab at Duke University has developed FoodSeq\, a genomic approach to track food intake through DNA sequencing of stool samples. In this talk\, I will explain how FoodSeq can identify and quantify dietary species\, allowing for objective and comprehensive monitoring of food consumption. We will explore the methodology behind FoodSeq\, including DNA extraction\, amplification\, and sequencing\, as well as data analysis. I will then present case studies demonstrating how FoodSeq can be used in clinical studies involving patients undergoing hematopoietic stem cell transplant\, highlighting the potential to contribute insights into nutrition\, health\, and the microbiome.
URL:https://www.ibs.re.kr/bimag/event/foodseq-using-genomics-to-track-and-study-diet-lawrence-david/
LOCATION:Conference room\, (B109)\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/04/0604222-e1745139516483.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
END:VCALENDAR