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TZID:Asia/Seoul
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DTSTART:20250101T000000
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DTSTART;TZID=Asia/Seoul:20260102T100000
DTEND;TZID=Asia/Seoul:20260102T113000
DTSTAMP:20260422T162242
CREATED:20251231T002614Z
LAST-MODIFIED:20251231T002614Z
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SUMMARY:Seasonal timing and interindividual differences in shiftwork adaptation - Kang Min Lee
DESCRIPTION:In this talk\, we discuss the paper “Seasonal timing and interindividual differences in shiftwork adaptation” by R. Kim et al.\, npj digital medicine\, 2025. \nAbstract  \nMillions of shift workers in the U.S. face an increased risk of depression\, cancer\, and metabolic disease\, yet individual responses to shift work vary widely. We find that a conserved biological system of morning and evening oscillators\, which evolved for seasonal timing\, may contribute to these interindividual differences. In this study\, we analyze seasonality in medical interns working shifts\, revealing that summer-winter variation correlates with increased circadian misalignment after shift work. Mathematical modeling suggests that seasonal timing influences the rate of adaptation to new schedules\, predicting differential effects on morning and evening oscillators. Additionally\, we examine genetic polymorphisms linked to seasonality in animals and find that human variants can impact how quickly circadian rhythms respond to schedule changes. Based on our findings\, we hypothesize that the vast interindividual differences in shift work adaptation—critical for shift worker health—can in part be explained by biological mechanisms for seasonal timing.
URL:https://www.ibs.re.kr/bimag/event/seasonal-timing-and-interindividual-differences-in-shiftwork-adaptation-kang-min-lee/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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