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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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BEGIN:VTIMEZONE
TZID:Asia/Seoul
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TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20230101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20240312T163000
DTEND;TZID=Asia/Seoul:20240312T183000
DTSTAMP:20260424T135040
CREATED:20240228T005750Z
LAST-MODIFIED:20240307T011616Z
UID:9273-1710261000-1710268200@www.ibs.re.kr
SUMMARY:Brenda Lyn Gavina\, Reduced model for female endocrine dynamics: Validation and functional variations
DESCRIPTION:We will discuss about “Reduced model for female endocrine dynamics: Validation and functional variations.” Mathematical Biosciences 358 (2023): 108979. \nAbstract \n\n\n\n\nA normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle disruption\, particularly given the large number of unknown parameters in existing mathematical models. We develop a new endocrine model to limit model complexity and use simulated distributions of unknown parameters for model analysis. By employing a comprehensive model evaluation\, we identify a collection of mechanisms that differentiate normal and abnormal phenotypes. We also discover an intermediate phenotype—displaying relatively normal hormone levels and cycle dynamics—that is grouped statistically with the irregular phenotype. Results provide insight into how clinical symptoms associated with ovulatory disruption may not be detected through hormone measurements alone. \n 
URL:https://www.ibs.re.kr/bimag/event/2024-03-13-jc/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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