BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Biomedical Mathematics Group - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20230101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20240202T140000
DTEND;TZID=Asia/Seoul:20240202T170000
DTSTAMP:20260424T153637
CREATED:20240127T064735Z
LAST-MODIFIED:20240128T132151Z
UID:9148-1706882400-1706893200@www.ibs.re.kr
SUMMARY:Yun Min Song\, A trade-off in controlling upstream and downstream noise in signaling networks
DESCRIPTION:We will discuss about “A trade-off in controlling upstream and downstream noise in signaling networks”\,  bioRxiv (2023): 2023-08. \n  \nAbstract\nSignal transduction\, underpinning the function of a variety of biological systems\, is inevitably affected by fluctuations. It remains intriguing how the timescale of a signaling network relates to its capability of noise control\, specifically\, whether long timescale can average out fluctuation or accumulate fluctuation. Here\, we consider two noise components of the signaling system: the upstream noise from the fluctuation of the input signal and the downstream noise from the stochastic fluctuations of the network. We discover a fundamental trade-off in controlling the upstream and downstream noise: a longer timescale of the signaling network can buffer upstream noise\, while accumulate downstream noise. Moreover\, we confirm that this trade-off relation exists in real biological signaling networks such as a fold-change detection circuit and the p53 activation signaling system.
URL:https://www.ibs.re.kr/bimag/event/2024-02-02-jc/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
END:VCALENDAR