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X-WR-CALDESC:Events for Biomedical Mathematics Group
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DTSTART:20220101T000000
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DTSTART;TZID=Asia/Seoul:20230908T140000
DTEND;TZID=Asia/Seoul:20230908T160000
DTSTAMP:20260425T124635
CREATED:20230829T100233Z
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UID:8369-1694181600-1694188800@www.ibs.re.kr
SUMMARY:Dongju Lim\, Exact solution of a three-stage model of stochastic gene expression including cell-cycle dynamics
DESCRIPTION:We will discuss about “Exact solution of a three-stage model of stochastic gene expression including cell-cycle dynamics”\, Wang\, Yiling\, et al.\, bioRxiv (2023): 2023-08. \n  \nAbstract \n\n\n\n\n\n\nThe classical three-stage model of stochastic gene expression predicts the statistics of single cell mRNA and protein number fluctuations as a function of the rates of promoter switching\, transcription\, translation\, degradation and dilution. While this model is easily simulated\, its analytical solution remains an unsolved problem. Here we modify this model to explicitly include cell-cycle dynamics and then derive an exact solution for the time-dependent joint distribution of mRNA and protein numbers. We show large differences between this model and the classical model which captures cell-cycle effects implicitly via effective first-order dilution reactions. In particular we find that the Fano factor of protein numbers calculated from a population snapshot measurement are underestimated by the classical model whereas the correlation between mRNA and protein can be either over- or underestimated\, depending on the timescales of mRNA degradation and promoter switching relative to the mean cell-cycle duration time. \n 
URL:https://www.ibs.re.kr/bimag/event/2023-09-08-jc/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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