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X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20210101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20221021T150000
DTEND;TZID=Asia/Seoul:20221021T170000
DTSTAMP:20260426T100956
CREATED:20220930T035045Z
LAST-MODIFIED:20221019T070546Z
UID:6641-1666364400-1666371600@www.ibs.re.kr
SUMMARY:Rhythmicity is linked to expression cost at the protein level but to expression precision at the mRNA level
DESCRIPTION:We will discuss about “Rhythmicity is linked to expression cost at the protein level but to expression precision at the mRNA level”\, David Laloum\, and Marc Robinson-Rechavi\, PLoS computational biology 18.9 (2022): e1010399. \nAbstract: \nMany genes have nycthemeral rhythms of expression\, i.e. a 24-hours periodic variation\, at either mRNA or protein level or both\, and most rhythmic genes are tissue-specific. Here\, we investigate and discuss the evolutionary origins of rhythms in gene expression. Our results suggest that rhythmicity of protein expression could have been favored by selection to minimize costs. Trends are consistent in bacteria\, plants and animals\, and are also supported by tissue-specific patterns in mouse. Unlike for protein level\, cost cannot explain rhythm at the RNA level. We suggest that instead it allows to periodically reduce expression noise. Noise control had the strongest support in mouse\, with limited evidence in other species. We have also found that genes under stronger purifying selection are rhythmically expressed at the mRNA level\, and we propose that this is because they are noise sensitive genes. Finally\, the adaptive role of rhythmic expression is supported by rhythmic genes being highly expressed yet tissue-specific. This provides a good evolutionary explanation for the observation that nycthemeral rhythms are often tissue-specific.
URL:https://www.ibs.re.kr/bimag/event/2022-10-21-jc/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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