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X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20210101T000000
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DTSTART;TZID=Asia/Seoul:20220616T130000
DTEND;TZID=Asia/Seoul:20220616T140000
DTSTAMP:20260426T203917
CREATED:20220615T190000Z
LAST-MODIFIED:20220623T060231Z
UID:6124-1655384400-1655388000@www.ibs.re.kr
SUMMARY:Identifying the critical states of complex diseases by the dynamic change of multivariate distribution
DESCRIPTION:We will discuss about “Identifying the critical states of complex diseases by the dynamic change of multivariate distribution”\, Peng\, Hao\, et al.\, Briefings in Bioinformatics\, 2022. \nAbstract: The dynamics of complex diseases are not always smooth; they are occasionally abrupt\, i.e. there is a critical state transition or tipping point at which the disease undergoes a sudden qualitative shift. There are generally a few significant differences in the critical state in terms of gene expressions or other static measurements\, which may lead to the failure of traditional differential expression-based biomarkers to identify such a tipping point. In this study\, we propose a computational method\, the direct interaction network-based divergence\, to detect the critical state of complex diseases by exploiting the dynamic changes in multivariable distributions inferred from observable samples and local biomolecular direct interaction networks. Such a method is model-free and applicable to both bulk and single-cell expression data. Our approach was validated by successfully identifying the tipping point just before the occurrence of a critical transition for both a simulated data set and seven real data sets\, including those from The Cancer Genome Atlas and two single-cell RNA-sequencing data sets of cell differentiation. Functional and pathway enrichment analyses also validated the computational results from the perspectives of both molecules and networks.
URL:https://www.ibs.re.kr/bimag/event/2022-06-16-jc-2/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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