BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Biomedical Mathematics Group - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20210101T000000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220311T130000
DTEND;TZID=Asia/Seoul:20220311T140000
DTSTAMP:20260427T020841
CREATED:20220303T190000Z
LAST-MODIFIED:20220224T015356Z
UID:5558-1647003600-1647007200@www.ibs.re.kr
SUMMARY:Transcription factor competition facilitates self-sustained oscillations in single gene genetic circuits
DESCRIPTION:Abstract: Genetic feedback loops can be used by cells as a means to regulate internal processes or keep track of time. It is often thought that\, for a genetic circuit to display self-sustained oscillations\, a degree of cooperativity is needed in the binding and unbinding of actor species. This cooperativity is usually modeled using a Hill function\, regardless of the actual promoter architecture. Moreover\, genetic circuits do not operate in isolation and often transcription factors are shared between different promoters. In this work we show how mathematical modelling of genetic feedback loops can be facilitated with a mechanistic fold-change function that takes into account the titration effect caused by competing binding sites for transcription factors. The model shows how the titration effect aids self-sustained oscillations in a minimal genetic feedback loop: a gene that produces its own repressor directly — without cooperative transcription factor binding. The use of delay differential equations leads to a stability contour that predicts whether a genetic feedback loop will show self-sustained oscillations\, even when taking the bursty nature of transcription into account. \n 
URL:https://www.ibs.re.kr/bimag/event/2022-03-04/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
END:VCALENDAR