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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20200101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20210917T130000
DTEND;TZID=Asia/Seoul:20210917T140000
DTSTAMP:20260427T124228
CREATED:20210915T190000Z
LAST-MODIFIED:20210831T052758Z
UID:4908-1631883600-1631887200@www.ibs.re.kr
SUMMARY:The Oscillation Amplitude\, Not the Frequency of Cytosolic Calcium\, Regulates Apoptosis Induction
DESCRIPTION:We will discuss about “The Oscillation Amplitude\, Not the Frequency of Cytosolic Calcium\, Regulates Apoptosis Induction ”\, Qi et al.\, iScience\, 2020 \nAbstract: \nAlthough a rising concentration of cytosolic Ca2+ has long been recognized as an essential signal for apoptosis\, the dynamical mechanisms by which Ca2+ regulates apoptosis are not clear yet. To address this\, we constructed a computational model that integrates known biochemical reactions and can reproduce the dynamical behaviors of Ca2+-induced apoptosis as observed in experiments. Model analysis shows that oscillating Ca2+ signals first convert into gradual signals and eventually transform into a switch-like apoptotic response. Via the two processes\, the apoptotic signaling pathway filters the frequency of Ca2+ oscillations effectively but instead responds acutely to their amplitude. Collectively\, our results suggest that Ca2+ regulates apoptosis mainly via oscillation amplitude\, rather than frequency\, modulation. This study not only provides a comprehensive understanding of how oscillatory Ca2+ dynamically regulates the complex apoptotic signaling network but also presents a typical example of how Ca2+ controls cellular responses through amplitude modulation.
URL:https://www.ibs.re.kr/bimag/event/2021-09-17/
LOCATION:B305 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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