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PRODID:-//Biomedical Mathematics Group - ECPv6.15.20//NONSGML v1.0//EN
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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20200101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20210409T120000
DTEND;TZID=Asia/Seoul:20210409T130000
DTSTAMP:20260428T010612
CREATED:20210323T105030Z
LAST-MODIFIED:20210407T041048Z
UID:4304-1617969600-1617973200@www.ibs.re.kr
SUMMARY:Highly accurate fluorogenic DNA sequencing with information theory–based error correction
DESCRIPTION:We will discuss about “Highly accurate fluorogenic DNA sequencing with information theory–based error correction”\, Chen et al.\, Nature Biotechnology (2017) \nEliminating errors in next-generation DNA sequencing has proved challenging. Here we present error-correction code (ECC) sequencing\, a method to greatly improve sequencing accuracy by combining fluorogenic sequencing-by-synthesis (SBS) with an information theory–based error-correction algorithm. ECC embeds redundancy in sequencing reads by creating three orthogonal degenerate sequences\, generated by alternate dual-base reactions. This is similar to encoding and decoding strategies that have proved effective in detecting and correcting errors in information communication and storage. We show that\, when combined with a fluorogenic SBS chemistry with raw accuracy of 98.1%\, ECC sequencing provides single-end\, error-free sequences up to 200 bp. ECC approaches should enable accurate identification of extremely rare genomic variations in various applications in biology and medicine. \n  \n 
URL:https://www.ibs.re.kr/bimag/event/2021-04-09/
LOCATION:B305 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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