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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20200101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20210401T120000
DTEND;TZID=Asia/Seoul:20210401T130000
DTSTAMP:20260427T231324
CREATED:20210331T003338Z
LAST-MODIFIED:20210406T075108Z
UID:4352-1617278400-1617282000@www.ibs.re.kr
SUMMARY:Yun Min Song\, A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light
DESCRIPTION:We will discuss about “A stochastic oscillator model simulates the entrainment of vertebrate cellular clocks by light”\, Kumpost et al.\, bioRxiv (2021) \nThe circadian clock is a cellular mechanism that synchronizes various biological processes with respect to the time of the day. While much progress has been made characterizing the molecular mechanisms underlying this clock\, it is less clear how external light cues influence the dynamics of the core clock mechanism and thereby entrain it with the light-dark cycle. Zebrafish-derived cell cultures possess clocks that are directly light-entrainable\, thus providing an attractive laboratory model for circadian entrainment. Here\, we have developed a stochastic oscillator model of the zebrafish circadian clock\, which accounts for the core clock negative feedback loop\, light input\, and the proliferation of single-cell oscillator noise into population-level luminescence recordings. The model accurately predicts the entrainment dynamics observed in bioluminescent clock reporter assays upon exposure to a wide range of lighting conditions. Furthermore\, we have applied the model to obtain refitted parameter sets for cell cultures exposed to a variety of pharmacological treatments and predict changes in single-cell oscillator parameters. Our work paves the way for model-based\, large-scale screens for genetic or pharmacologically-induced modifications to the entrainment of circadian clock function.
URL:https://www.ibs.re.kr/bimag/event/2021-04-02/
LOCATION:B305 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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