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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20200101T000000
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DTSTART;TZID=Asia/Seoul:20210305T130000
DTEND;TZID=Asia/Seoul:20210305T140000
DTSTAMP:20260428T010835
CREATED:20210228T074756Z
LAST-MODIFIED:20210406T075234Z
UID:4157-1614949200-1614952800@www.ibs.re.kr
SUMMARY:Eui Min Jeong\, Pairing of segmentation clock genes drives robust pattern formation
DESCRIPTION:We will discuss about “Pairing of segmentation clock genes drives robust pattern formation”\, Zinani et al.\, Nature (2021) \nGene expression is an inherently stochastic process; however\, organismal development and homeostasis require cells to coordinate the spatiotemporal expression of large sets of genes. In metazoans\, pairs of co-expressed genes often reside in the same chromosomal neighbourhood\, with gene pairs representing 10 to 50% of all genes\, depending on the species. Because shared upstream regulators can ensure correlated gene expression\, the selective advantage of maintaining adjacent gene pairs remains unknown6. Here\, using two linked zebrafish segmentation clock genes\, her1 and her7\, and combining single-cell transcript counting\, genetic engineering\, real-time imaging and computational modelling\, we show that gene pairing boosts correlated transcription and provides phenotypic robustness for the formation of developmental patterns. Our results demonstrate that the prevention of gene pairing disrupts oscillations and segmentation\, and the linkage of her1 and her7 is essential for the development of the body axis in zebrafish embryos. We predict that gene pairing may be similarly advantageous in other organisms\, and our findings could lead to the engineering of precise synthetic clocks in embryos and organoids \n  \n 
URL:https://www.ibs.re.kr/bimag/event/2021-03-05/
LOCATION:Tea Room\, IBS\, Daejeon\, Daejeon\, 34141\, Korea\, Republic of
CATEGORIES:Journal Club,Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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