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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20200101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20210121T140000
DTEND;TZID=Asia/Seoul:20210121T160000
DTSTAMP:20260428T063818
CREATED:20210223T094006Z
LAST-MODIFIED:20210406T075136Z
UID:3980-1611237600-1611244800@www.ibs.re.kr
SUMMARY:Seokjoo Chae\, Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression
DESCRIPTION:We will discuss about “Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression”\, Benzinger et al.\, bioRxiv (2021) \nCells live in constantly changing environments and employ dynamic signaling pathways to transduce information about the signals they encounter. However\, the mechanisms by which dynamic signals are decoded into appropriate gene expression patterns remain poorly understood. Here\, we devise networked optogenetic pathways that achieve novel dynamic signal processing functions that recapitulate cellular information processing. Exploiting light-responsive transcriptional regulators with differing response kinetics\, we build a falling-edge pulse-detector and show that this circuit can be employed to demultiplex dynamically encoded signals. We combine this demultiplexer with dCas9-based gene networks to construct pulsatile-signal filters and decoders. Applying information theory\, we show that dynamic multiplexing significantly increases the information transmission capacity from signal to gene expression state. Finally\, we use dynamic multiplexing for precise multidimensional regulation of a heterologous metabolic pathway. Our results elucidate design principles of dynamic information processing and provide original synthetic systems capable of decoding complex signals for biotechnological applications. \n 
URL:https://www.ibs.re.kr/bimag/event/2021-01-21_1/
LOCATION:KAIST E2-1 room 3221\, E2-1 building\, Daejeon\, Daejeon\, 34141\, Korea\, Republic of
CATEGORIES:Journal Club,Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20210129T140000
DTEND;TZID=Asia/Seoul:20210129T160000
DTSTAMP:20260428T063818
CREATED:20210223T092935Z
LAST-MODIFIED:20210406T075248Z
UID:3978-1611928800-1611936000@www.ibs.re.kr
SUMMARY:Yun Min Song\, On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism
DESCRIPTION:We will discuss about “On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism”\, bioRxiv (2021). \nThe conditions for the validity of the standard quasi-steady-state approximation in the Michaelis–Menten mechanism in a closed reaction vessel have been well studied\, but much less so the conditions for the validity of this approximation for the system with substrate inflow. We analyze quasi-steady-state scenarios for the open system attributable to singular perturbations\, as well as less restrictive conditions. For both settings we obtain distinguished invariant slow manifolds and time scale estimates\, and we highlight the special role of singular perturbation parameters in higher order approximations of slow manifolds. We close the paper with a discussion of distinguished invariant manifolds in the global phase portrait. \n 
URL:https://www.ibs.re.kr/bimag/event/2021-01-29/
LOCATION:KAIST E2-1 room 3221\, E2-1 building\, Daejeon\, Daejeon\, 34141\, Korea\, Republic of
CATEGORIES:Journal Club,Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
END:VCALENDAR