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X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20250101T000000
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DTSTART;TZID=Asia/Seoul:20260320T100000
DTEND;TZID=Asia/Seoul:20260320T113000
DTSTAMP:20260404T082128
CREATED:20260304T051107Z
LAST-MODIFIED:20260304T051107Z
UID:12253-1774000800-1774006200@www.ibs.re.kr
SUMMARY:Temporal tissue dynamics from a spatial snapshot - Kang Min Lee
DESCRIPTION:In this talk\, we discuss the paper “Temporal tissue dynamics from a spatial snapshot” by Jonathan Somer et al.\, Nature\, 2026. \nAbstract \nPhysiological and pathological processes such as inflammation and cancer emerge from interactions between cells over time1. However\, methods to follow cell populations over time within the native context of a human tissue are lacking because a biopsy offers only a single snapshot. Here we present one-shot tissue dynamics reconstruction (OSDR)\, an approach to estimate a dynamical model of cell populations based on a single tissue sample. OSDR uses spatial proteomics to learn how the composition of cellular neighbourhoods influences division rate\, providing a dynamical model of cell population change over time. We apply OSDR to human breast cancer data2\,3\,4\, and reconstruct two fixed points of fibroblasts and macrophage interactions5\,6. These fixed points correspond to hot and cold fibrosis7\, in agreement with co-culture experiments that measured these dynamics directly8. We then use OSDR to discover a pulse-generating excitable circuit of T and B cells in the tumour microenvironment\, suggesting temporal flares of anticancer immune responses. Finally\, we study longitudinal biopsies from a triple-negative breast cancer clinical trial3\, in which OSDR predicts the collapse of the tumour cell population in responders but not in non-responders\, based on early-treatment biopsies. OSDR can be applied to a wide range of spatial proteomics assays to enable analysis of tissue dynamics based on patient biopsies.
URL:https://www.ibs.re.kr/bimag/event/temporal-tissue-dynamics-from-a-spatial-snapshot-kang-min-lee/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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