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X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20250101T000000
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DTSTART;TZID=Asia/Seoul:20260213T100000
DTEND;TZID=Asia/Seoul:20260213T113000
DTSTAMP:20260407T073318
CREATED:20260203T013928Z
LAST-MODIFIED:20260203T013928Z
UID:12166-1770976800-1770982200@www.ibs.re.kr
SUMMARY:Intelligent in-cell electrophysiology - Chitaranjan Mahapatra
DESCRIPTION:In this talk\, we discuss the paper “Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings” by K. Rahmani et al.\, Nat. Comm\, 2025. \nAbstract \nIntracellular electrophysiology is essential in neuroscience\, cardiology\, and pharmacology for studying cells’ electrical properties. Traditional methods like patch-clamp are precise but low-throughput and invasive. Nanoelectrode Arrays (NEAs) offer a promising alternative by enabling simultaneous intracellular and extracellular action potential (iAP and eAP) recordings with high throughput. However\, accessing intracellular potentials with NEAs remains challenging. This study presents an AI-supported technique that leverages thousands of synchronous eAP and iAP pairs from stem-cell-derived cardiomyocytes on NEAs. Our analysis revealed strong correlations between specific eAP and iAP features\, such as amplitude and spiking velocity\, indicating that extracellular signals could be reliable indicators of intracellular activity. We developed a physics-informed deep learning model to reconstruct iAP waveforms from extracellular recordings recorded from NEAs and Microelectrode arrays (MEAs)\, demonstrating its potential for non-invasive\, long-term\, high-throughput drug cardiotoxicity assessments. This AI-based model paves the way for future electrophysiology research across various cell types and drug interactions.
URL:https://www.ibs.re.kr/bimag/event/intelligent-in-cell-electrophysiology-chitaranjan-mahapatra/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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