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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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DTSTART:20240101T000000
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DTSTART;TZID=Asia/Seoul:20250328T110000
DTEND;TZID=Asia/Seoul:20250328T120000
DTSTAMP:20260521T231353
CREATED:20250217T075911Z
LAST-MODIFIED:20250217T081432Z
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SUMMARY:Dynamics and Decision Making in Single Cells - Galit Lahav
DESCRIPTION:Abstract \nIndividual human cancer cells often show different responses to the same treatment. In this talk I will share the quantitative experimental approaches my lab has developed for studying the fate and behavior of human cells at the single-cell level. I will focus on the tumor suppressor protein p53\, a transcription factor controlling genomic integrity and cell survival. In the last several years we have established the dynamics of p53 (changes in its levels over time) as an important mechanism controlling gene expression and guiding cellular outcomes. I will present recent studies from the lab demonstrating how studying p53 dynamics in response to radiation and chemotherapy in single cells can guide the design and schedule of combinatorial therapy\, and how the p53 oscillator can be used to study the principles and function of entertainment in Biology. I will also present new findings suggesting that p53’s post-translational modification state is altered between its first and second pulses of expression\, and the effects these have on gene expression programs over time.
URL:https://www.ibs.re.kr/bimag/event/dynamics-and-decision-making-in-single-cells-galit-lahav/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/png:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2025/02/Galit-Lahav-e1739779209180.png
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20250328T140000
DTEND;TZID=Asia/Seoul:20250328T160000
DTSTAMP:20260521T231353
CREATED:20250302T133447Z
LAST-MODIFIED:20250327T010923Z
UID:10853-1743170400-1743177600@www.ibs.re.kr
SUMMARY:Frequency-Dependent Covariance Reveals Critical Spatiotemporal Patterns of Synchronized Activity in the Human Brain - Hyun Kim
DESCRIPTION:In this talk\, we discuss the paper “Frequency-Dependent Covariance Reveals Critical Spatiotemporal Patterns of Synchronized Activity in the Human Brain” by Rubén Calvo et al.\, Physical Review Letters 2024\, at the Journal Club. \nAbstract \nRecent analyses\, leveraging advanced theoretical techniques and high-quality data from thousands of simultaneously recorded neurons across regions in the brain\, compellingly support the hypothesis that neural dynamics operate near the edge of instability. However\, these and related analyses often fail to capture the intricate temporal structure of brain activity\, as they primarily rely on time-integrated measurements across neurons. Here\, we present a novel framework designed to explore signatures of criticality across diverse frequency bands and construct a much more comprehensive description of brain activity. Furthermore\, we introduce a method for projecting brain activity onto a basis of spatiotemporal patterns\, facilitating time-dependent dimensionality reduction. Applying this framework to a magnetoencephalography dataset\, we observe significant differences in criticality signatures\, effective dimensionality\, and spatiotemporal activity patterns between healthy subjects and individuals with Parkinson’s disease\, highlighting its potential impact.
URL:https://www.ibs.re.kr/bimag/event/journal-club-hyun-kim/
LOCATION:Daejeon
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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