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X-WR-CALDESC:Events for Biomedical Mathematics Group
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DTSTART:20220101T000000
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DTSTART;TZID=Asia/Seoul:20230901T100000
DTEND;TZID=Asia/Seoul:20230901T120000
DTSTAMP:20260426T045013
CREATED:20230810T082738Z
LAST-MODIFIED:20230831T040832Z
UID:8236-1693562400-1693569600@www.ibs.re.kr
SUMMARY:Hyeongjun Jang\, Generalized Michaelis–Menten rate law with time-varying molecular concentrations
DESCRIPTION:We will discuss about “Generalized Michaelis–Menten rate law with time-varying molecular concentrations”\, Lim\, Roktaek\, et al.\,bioRxiv (2022): 2022-01 \n  \nAbstract \n\n\n\n\n\n\nThe Michaelis–Menten (MM) rate law has been the dominant paradigm of modeling biochemical rate processes for over a century with applications in biochemistry\, biophysics\, cell biology\, and chemical engineering. The MM rate law and its remedied form stand on the assumption that the concentration of the complex of interacting molecules\, at each moment\, approaches an equilibrium much faster than the molecular concentrations change. Yet\, this assumption is not always justified. Here\, we relax this quasi-steady state requirement and propose the generalized MM rate law for the interactions of molecules with active concentration changes over time. Our approach for time-varying molecular concentrations\, termed the effective time-delay scheme (ETS)\, is based on rigorously estimated time-delay effects in molecular complex formation. With particularly marked improvements in protein– protein and protein–DNA interaction modeling\, the ETS provides an analytical framework to interpret and predict rich transient or rhythmic dynamics (such as autogenously-regulated cellular adaptation and circadian protein turnover)\, which goes beyond the quasi-steady state assumption.
URL:https://www.ibs.re.kr/bimag/event/2023-09-01-jc/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Journal Club
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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