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X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20210101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20221007T103000
DTEND;TZID=Asia/Seoul:20221007T110000
DTSTAMP:20260425T082840
CREATED:20220825T011010Z
LAST-MODIFIED:20220901T010141Z
UID:6468-1665138600-1665140400@www.ibs.re.kr
SUMMARY:A Dynamic Paradigm for Molecular Cell Biology
DESCRIPTION:Abstract: The driving passion of molecular cell biologists is to understand the molecular mechanisms that control important aspects of cell physiology\, but this ambition is – paradoxically – limited by the very wealth of molecular details currently known about these mechanisms. Their complexity overwhelms our intuitive notions of how molecular regulatory networks might respond under normal and stressful conditions. To make progress we need a new paradigm for connecting molecular biology to cell physiology. I will outline an approach that uses precise mathematical methods to associate the qualitative features of dynamical systems\, as conveyed by ‘bifurcation diagrams’\, with ‘signal–response’ curves measured by cell biologists.
URL:https://www.ibs.re.kr/bimag/event/2022-10-01-colloquium1/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/png:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2022/08/Tyson_profile-250x250-1.png
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20221007T110000
DTEND;TZID=Asia/Seoul:20221007T120000
DTSTAMP:20260425T082840
CREATED:20220825T011205Z
LAST-MODIFIED:20220901T005901Z
UID:6471-1665140400-1665144000@www.ibs.re.kr
SUMMARY:Time-keeping and Decision-making in the Cell Cycle
DESCRIPTION:Abstract: Cell growth\, DNA replication\, mitosis and division are the fundamental processes by which life is passed on from one generation of eukaryotic cells to the next. The eukaryotic cell cycle is intrinsically a periodic process but not so much a ‘clock’ as a ‘copy machine’\, making new daughter cells as warranted. Cells growing under ideal conditions divide with clock-like regularity; however\, if they are challenged with DNA-damaging agents or mitotic spindle disruptors\, they will not progress to the next stage of the cycle until the damage is repaired. These ‘decisions’ (to exit and re-enter the cell cycle) are essential to maintain the integrity of the genome from generation to generation. A crucial challenge for molecular cell biologists in the 1990s was to unravel the genetic and biochemical mechanisms of cell cycle control in eukaryotes. Central to this effort were biochemical studies of the clock-like regulation of ‘mitosis promoting factor’ during synchronous mitotic cycles of fertilized frog eggs and genetic studies of the switch-like regulation of ‘cyclin-dependent kinases’ in yeast cells. The complexity of these control systems demands a dynamical approach\, as described in the first lecture. Using mathematical models of the control systems\, I will uncover some of the secrets of cell cycle ‘clocks’ and ‘switches’.
URL:https://www.ibs.re.kr/bimag/event/2022-10-07-colloquium2/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/png:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2022/08/Tyson_profile-250x250-1.png
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
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