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X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZOFFSETFROM:+0900
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DTSTART:20210101T000000
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DTSTART;TZID=Asia/Seoul:20220615T160000
DTEND;TZID=Asia/Seoul:20220615T170000
DTSTAMP:20260425T051745
CREATED:20220613T144731Z
LAST-MODIFIED:20220613T144731Z
UID:6188-1655308800-1655312400@www.ibs.re.kr
SUMMARY:Optimized persistent random walk in zebrafish airineme search process
DESCRIPTION:In addition to diffusive signals\, cells in tissue also communicate via long\, thin cellular protrusions\, such as airinemes in zebrafish. Before establishing communication\, cellular protrusions must find their target cell. In this talk\, we demonstrate that the shapes of airinemes in zebrafish are consistent with a persistent random walk model. The probability of contacting the target cell is maximized for a balance between ballistic search (straight) and diffusive search (highly curved\, random). We find that the curvature of airinemes in zebrafish\, extracted from live cell microscopy\, is approximately the same value as the optimum in the simple persistent random walk model. We also explore the ability of the target cell to infer direction of the airineme’s source\, finding that there is a theoretical trade-off between search optimality and directional information. This provides a framework to characterize the shape\, and performance objectives\, of non-canonical cellular protrusions in general.
URL:https://www.ibs.re.kr/bimag/event/2022-06-15-seminar-hjkim/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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