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PRODID:-//Biomedical Mathematics Group - ECPv6.15.20//NONSGML v1.0//EN
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X-WR-CALDESC:Events for Biomedical Mathematics Group
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TZID:Asia/Seoul
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TZOFFSETFROM:+0900
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DTSTART:20200101T000000
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DTSTART;TZID=Asia/Seoul:20211021T110000
DTEND;TZID=Asia/Seoul:20211021T120000
DTSTAMP:20260510T034900
CREATED:20211103T170000Z
LAST-MODIFIED:20210930T040222Z
UID:4787-1634814000-1634817600@www.ibs.re.kr
SUMMARY:Scaling in development
DESCRIPTION:This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234)\n\nAbstract: \n Within a given species\, fluctuations in egg or embryo size is unavoidable. Despite this\, the gene expression pattern and hence the embryonic structure often scale in proportion with the body length. This scaling phenomenon is very common in development and regeneration and has long fascinated scientists. I will first discuss a generic theoretical framework to show how scaling gene expression pattern can emerge from non-scaling morphogen gradients. I will then demonstrate that the Drosophila gap gene system achieves scaling in a way that is entirely consistent with our theory. Remarkably\, a parameter-free model based on the theory quantitatively accounts for the gap gene expression pattern in nearly all morphogen mutants. Furthermore\, the regulation logic and the coding/decoding strategy of the gap gene system can be revealed. Our work provides a general theoretical framework on a large class of problems where scaling output is induced by non-scaling input\, as well as a unified understanding of scaling\, mutants’ behavior and regulation in the Drosophila gap gene and related systems.
URL:https://www.ibs.re.kr/bimag/event/2021-10-21/
LOCATION:ZOOM ID: 709 120 4849 (ibsbimag)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/png:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2021/07/resize.png
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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