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X-WR-CALDESC:Events for Biomedical Mathematics Group
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DTSTART:20200101T000000
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DTSTART;TZID=Asia/Seoul:20211007T110000
DTEND;TZID=Asia/Seoul:20211007T120000
DTSTAMP:20260510T051242
CREATED:20211006T170000Z
LAST-MODIFIED:20211230T031435Z
UID:4850-1633604400-1633608000@www.ibs.re.kr
SUMMARY:A temporal signaling code to specify immune responses
DESCRIPTION:This talk will be presented online. Zoom link: 709 120 4849 (pw: 1234) \nAbstract: \nImmune sentinel cells must initiate the appropriate immune response upon sensing the presence of diverse pathogens or immune stimuli. To generate stimulus-specific gene expression responses\, immune sentinel cells have evolved a temporal code in the dynamics of stimulus responsive transcription factors. I will present recent works 1) using an information theoretic approach to identify the codewords\, termed “signaling codons”\, 2) using a machine learning approach to characterize their reliability and points of confusion\, and 3) dynamical systems modeling to characterize the molecular circuits that allow for their encoding. I will present progress on how the temporal code may be decoded to specify immune responses.  Further\, I will discuss to what extent such a code may be harnessed to achieve greater pharmacological specificity when therapeutically targeting pleiotropic signaling hubs. \nNFκB Signaling: information theory\, signaling codons \nAdelaja\, A.\, Taylor\, B.\, Sheu\, K.M.\, Liu\, Y.\, Luecke\, S.\, Hoffmann\, A. 2021 Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity\, 54\, pp.916-930. e7. PMID: 33979588 \nTang\, Y.\, Adelaja\, A.\, Ye\, X\, Deeds\, E.\, Wollman\, R.\, Hoffmann\, A. 2021. Quantifying information accumulation encoded in the dynamics of biochemical signaling. Nature Communications 12\, pp.1-10 \nDecoding signaling codons to specify immune responses \nSen S.\, Cheng\, Z.\, Sheu\, K.\, Chen\, E.Y.H.\, Hoffmann\, A. 2020 Gene Regulatory Strategies that Decode the Duration of NFkB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression. Cell Systems\, 10\, pp.1-14. PMID:31972132\, PMC7047529 \nCheng\, Q.J.\, Ohta\, S.\, Sheu\, K.M.\, Spreafico\, R.\, Adelaja\, A.\, Taylor\, B.\, Hoffmann\, A.  2021 NFκB dynamics determine the stimulus-specificity of epigenomic reprogramming in macrophages. Science\, 372\, pp.1349-1353; PMID: 34140389. \nPharmacologic manipulation of the code \nBehar\, M.\, Barken\, D.\, Werner\, S.L.\, Hoffmann\, A. 2013  The Dynamics of Signaling as a Pharmacological Target.  Cell\, 155\, pp.448-461. PMID: 24120141\, PMC3856316
URL:https://www.ibs.re.kr/bimag/event/2021-10-07/
LOCATION:ZOOM ID: 709 120 4849 (ibsbimag)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/png:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2021/10/AlexanderHoffmann_profile_250x250.png
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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