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DTSTART:20240101T000000
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DTSTART;TZID=Asia/Seoul:20250806T150000
DTEND;TZID=Asia/Seoul:20250806T170000
DTSTAMP:20260430T104944
CREATED:20250804T010321Z
LAST-MODIFIED:20250824T041110Z
UID:11368-1754492400-1754499600@www.ibs.re.kr
SUMMARY:Jooyoung Hahn - Topological Data Analysis with two applications: Tumor Microenvironment and  2D Chromatography with High-Resolution Mass Spectrometry
DESCRIPTION:Abstract  \nTopological Data Analysis (TDA) has emerged as a powerful framework for uncovering meaningful structure in high-dimensional\, complex datasets. In this talk\, we present two applications of TDA in analyzing patterns\, one in the tumor microenvironment (TME) and the other in high-resolution chemical profiling. In the first case\, we develop a TDA-based framework to quantify malignant-immune cell interactions in Diffuse Large B Cell Lymphoma using multiplex immunofluorescence imaging. By introducing Topological Malignant Clusters (TopMC) and leveraging persistence diagrams\, we capture both global infiltration patterns and local density-based features. This robust approach enables consistent prognostic assessment regardless of tumor region heterogeneity and reveals correlations with patient survival. In the second application\, we utilize the Ball Mapper algorithm to simplify and visualize high-dimensional data obtained from 2D Chromatography with high-resolution mass spectrometry. This enables interpretable chemical profiling of complex mixtures and supports tasks such as sample authentication and environmental analysis. Together\, these studies demonstrate the versatility and interpretability of TDA for extracting biologically and chemically meaningful information. \nSeminar Video Link: https://www.youtube.com/watch?v=mz9pY6nk3n4&t=12s
URL:https://www.ibs.re.kr/bimag/event/jooyoung-hahn-topological-data-analysis-with-two-applications-tumor-microenvironment-and-2d-chromatography-with-high-resolution-mass-spectrometry/
LOCATION:B232 Seminar Room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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