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PRODID:-//Biomedical Mathematics Group - ECPv6.15.20//NONSGML v1.0//EN
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X-WR-CALNAME:Biomedical Mathematics Group
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
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BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20210101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220104T111000
DTEND;TZID=Asia/Seoul:20220104T120000
DTSTAMP:20260503T053119
CREATED:20220103T002320Z
LAST-MODIFIED:20220103T002320Z
UID:5432-1641294600-1641297600@www.ibs.re.kr
SUMMARY:Stem cell dynamics in the intestine and stomach
DESCRIPTION:In adult tissues\, stem cells undergo clonal competition because they proliferate while the stem cell niche provides limited space. This clonal competition allows the selection of healthy stem cells over time as unfit stem cells tend to lose from the competition. It could also be a mechanism to select a supercompetitor with tumorigenic mutations\, which may lead to tumorigenesis. I am going to explain general concepts of clonal competition and how a simple model can explain the behaviour of adult stem cells. I will also show how geometric constraints affect the overall dynamics of stem cell competition.
URL:https://www.ibs.re.kr/bimag/event/2022-01-03/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220105T160000
DTEND;TZID=Asia/Seoul:20220105T173000
DTSTAMP:20260503T053119
CREATED:20220104T220000Z
LAST-MODIFIED:20211224T001927Z
UID:5366-1641398400-1641403800@www.ibs.re.kr
SUMMARY:Structure-based analysis of chemical reaction networks 1/2
DESCRIPTION:Abstract: Inside living cells\, chemical reactions form a large web of networks. Understanding the behavior of those complex reaction networks is an important and challenging problem. In many situations\, it is hard to identify the details of the reactions\, such as the reaction kinetics and parameter values. It would be good if we can clarify what we can say about the behavior of reaction systems\, when we know the structure of reaction networks but reaction kinetics is unknown. In these talks\, I plan to introduce two approaches in this spirit. Firstly\, we will discuss the sensitivity analysis of reaction systems based on the structural information of reaction networks [1]. I will give an introduction to the method of identifying subnetworks inside which the effects of the perturbation of reaction parameters are confined. Secondly\, I will introduce the reduction method that we developed recently [2]. In those two methods\, an integer determined by the topology of a subnetwork\, which we call an influence index\, plays a crucial role. \nReferences \n[1] T. Okada\, A. Mochizuki\, “Law of Localization in Chemical Reaction Networks\,” Phys. Rev. Lett. 117\, 048101 (2016); T. Okada\, A. Mochizuki\, “Sensitivity and network topology in chemical reaction systems\,” Phys. Rev. E 96\, 022322 (2017). \n[2] Y. Hirono\, T. Okada\, H. Miyazaki\, Y. Hidaka\, “Structural reduction of chemical reaction networks based on topology”\, Phys. Rev. Research 3\, 043123 (2021).
URL:https://www.ibs.re.kr/bimag/event/2022-01-05/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220106T160000
DTEND;TZID=Asia/Seoul:20220106T173000
DTSTAMP:20260503T053119
CREATED:20220105T220000Z
LAST-MODIFIED:20211224T001917Z
UID:5369-1641484800-1641490200@www.ibs.re.kr
SUMMARY:Structure-based analysis of chemical reaction networks 2/2
DESCRIPTION:Inside living cells\, chemical reactions form a large web of networks. Understanding the behavior of those complex reaction networks is an important and challenging problem. In many situations\, it is hard to identify the details of the reactions\, such as the reaction kinetics and parameter values. It would be good if we can clarify what we can say about the behavior of reaction systems\, when we know the structure of reaction networks but reaction kinetics is unknown. In these talks\, I plan to introduce two approaches in this spirit. Firstly\, we will discuss the sensitivity analysis of reaction systems based on the structural information of reaction networks [1]. I will give an introduction to the method of identifying subnetworks inside which the effects of the perturbation of reaction parameters are confined. Secondly\, I will introduce the reduction method that we developed recently [2]. In those two methods\, an integer determined by the topology of a subnetwork\, which we call an influence index\, plays a crucial role. \n[1] T. Okada\, A. Mochizuki\, “Law of Localization in Chemical Reaction Networks\,” Phys. Rev. Lett. 117\, 048101 (2016); T. Okada\, A. Mochizuki\, “Sensitivity and network topology in chemical reaction systems\,” Phys. Rev. E 96\, 022322 (2017). \n[2] Y. Hirono\, T. Okada\, H. Miyazaki\, Y. Hidaka\, “Structural reduction of chemical reaction networks based on topology”\, Phys. Rev. Research 3\, 043123 (2021).
URL:https://www.ibs.re.kr/bimag/event/2022-01-06/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220118T160000
DTEND;TZID=Asia/Seoul:20220118T170000
DTSTAMP:20260503T053119
CREATED:20220117T220000Z
LAST-MODIFIED:20220115T115221Z
UID:5466-1642521600-1642525200@www.ibs.re.kr
SUMMARY:다중 오믹스 분야의 현황 및 유전자-환경 상호 모델링의 필요성 (Current status of multi-omics research field and necessity of gene-by-environment (GxE) interaction modeling)
DESCRIPTION:본 발표에서는 다양한 기초 생명-의학 분야에서 생성되고 있는 오믹스 자료의 연구 개발 현황에 대해서 다룰 예정이다. 보다 큰 규모로\, 보다 빠르게\, 보다 정확하게\, 보다 정밀하게 라는 궁극적인 목표하에 이뤄지고 있는 오믹스 자료의 진화에 발맞춰\, 이를 분석하는 수리통계적 모형 역시 진화하고 있다. 그 중\, 이번 발표에서는 미국의 초 대형 정밀의료 프로젝트인 TopMed에서 진행하고 있는 COPD에 관한 다중 오믹스 자료의 통합 분석 방법 및 결과에 대해서 자세히 다룰 예정이다. 아울러 정밀의료라는 목표를 달성하기 위해 반드시 모형에서 고려해야 하는 “환경 특이적 효과”에 대해 강연할 예정이다. \n 
URL:https://www.ibs.re.kr/bimag/event/2022-01-18/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220127T110000
DTEND;TZID=Asia/Seoul:20220127T130000
DTSTAMP:20260503T053119
CREATED:20220126T170000Z
LAST-MODIFIED:20220125T115708Z
UID:5507-1643281200-1643288400@www.ibs.re.kr
SUMMARY:Introduction to Bayesian Variable Selection.  
DESCRIPTION:Abstract:\nVariable selection is an approach to identifying a set of covariates that are truly important to explain the feature of a response variable. It is closely connected or belongs to model selection approaches. This talk provides a gentle introduction to Bayesian variable selection methods. The basic notion of variable selection is introduced\, followed by several Bayesian approaches with a simple application example.
URL:https://www.ibs.re.kr/bimag/event/2022-01-27-2/
LOCATION:B378 Seminar room\, IBS\, 55 Expo-ro Yuseong-gu\, Daejeon\, 34126\, Korea\, Republic of
CATEGORIES:Biomedical Mathematics Seminar
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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