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PRODID:-//Biomedical Mathematics Group - ECPv6.17.0//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://www.ibs.re.kr/bimag
X-WR-CALDESC:Events for Biomedical Mathematics Group
REFRESH-INTERVAL;VALUE=DURATION:PT1H
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BEGIN:VTIMEZONE
TZID:Asia/Seoul
BEGIN:STANDARD
TZOFFSETFROM:+0900
TZOFFSETTO:+0900
TZNAME:KST
DTSTART:20210101T000000
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BEGIN:VEVENT
DTSTART;TZID=Asia/Seoul:20220902T110000
DTEND;TZID=Asia/Seoul:20220902T120000
DTSTAMP:20220829T000006Z
CREATED:20220825T010806Z
LAST-MODIFIED:20220829T000006Z
UID:6463-1662116400-1662120000@www.ibs.re.kr
SUMMARY:Cell signaling in 2D vs. 3D
DESCRIPTION:Abstract: \nThe activation of Ras depends upon the translocation of its guanine nucleotide exchange factor\, Sos\, to the plasma membrane. Moreover\, artificially inducing Sos to translocate to the plasma membrane is sufficient to bring about Ras activation and activation of Ras’s targets. There are many other examples of signaling proteins that must translocate to the membrane in order to relay a signal. \nOne attractive idea is that translocation promotes signaling by bringing a protein closer to its target. However\, proteins that are anchored to the membrane diffuse more slowly than cytosolic proteins do\, and it is not clear whether the concentration effect or the diffusion effect would be expected to dominate. Here we have used a reconstituted\, controllable system to measure the association rate for the same binding reaction in 3D vs. 2D to see whether association is promoted\, and\, if so\, how.
URL:https://www.ibs.re.kr/bimag/event/20220902_colloquium/
LOCATION:ZOOM ID: 997 8258 4700 (Biomedical Mathematics Online Colloquium)\, (pw: 1234)
CATEGORIES:Biomedical Mathematics Online Colloquium
ATTACH;FMTTYPE=image/jpeg:https://www.ibs.re.kr/bimag/cms/wp-content/uploads/2022/08/Ferrell_profile-250x250-1.jpg
ORGANIZER;CN="Jae Kyoung Kim":MAILTO:jaekkim@kaist.ac.kr
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